BACKGROUND Combined oral contraceptives are a common method of contraception, but they carry a risk of venous and arterial thrombosis. We assessed whether use of drospirenone was associated with an increase in thrombotic risk relative to third-generation combined oral contraceptives. METHODS Using computerized records of the largest health care provider in Israel, we identified all women aged...

background most women taking combined oral contraceptives (cocs) are satisfied with their contraceptive method. however, one of the most common reasons reported for discontinuation of combined oral contraceptives (cocs) is mood deterioration. objectives this study aimed to compare effects of the second and third generation oral contraceptive pills on the mood of reproductive women. materials an...

OBJECTIVE To compare the incidence of venous thromboembolism among women taking combined oral contraceptives before and after the October 1995 pill scare. DESIGN Analysis of General Practice Research Database. SETTING United Kingdom, January 1993 to December 1998. SUBJECTS Women aged 15-49 taking combined oral contraceptives. MAIN OUTCOME MEASURES Incidence of venous thromboembolism. ...

2. Kemmeren JM, Algra A, Meijers JC, et al. Effect of secondand third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial. Blood. 2004;103:927-933. 3. Curvers J, Thomassen MC, Rimmer J, et al. Effects of hereditary and acquired risk factors of venous thrombosis on a thrombin generation-based APC resistance test. Th...

2. Kemmeren JM, Algra A, Meijers JC, et al. Effect of secondand third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial. Blood. 2004;103:927-933. 3. Curvers J, Thomassen MC, Rimmer J, et al. Effects of hereditary and acquired risk factors of venous thrombosis on a thrombin generation-based APC resistance test. Th...

BACKGROUND Epidemiological studies have shown that both the estrogen dose and progestogen type of oral contraceptives contribute to the increased risk of thrombosis in oral contraceptive users. Thrombin generation-based activated protein C (APC) sensitivity is a global test for the net prothrombotic effect of oral contraceptives and predicts the thrombotic risk. Our objective was to test the us...