GENIE is a scalable modular platform aiming to simulate the long term evolution of the Earth’s climate. It’s modularity lies in the fact that it consists of a separate module for the earth’s atmosphere, the oceans, the land, the sea-ice and the land-ice. Such models need to be coupled together to produce the ensemble model. As new modules are actively being researched and developed, it is desir...

This paper determines the sum-capacity of degraded Gaussian K-user interference channels (IFCs). To this end, the paper first develops a family of genie-MAC (multiple access channel) outer bounds for Gaussian K-user interference channels. This family is based on existing genie-aided bounding mechanisms, but differs from current approaches in its optimization problem formulation and application....

Genie selectionism holds that all selection can be understood as operating on particular genes. Critics (and conventional biological wisdom) insist that this misrep? resents the actual causal structure of selective phenomena at higher levels of biological organization, but cannot convincingly defend this intuition. I argue that the real failing of genie selectionism is pragmatic it prevents us ...

A hidden Markov model-based gene-finding system called Genie was applied to the genomic Adh region in Drosophila melanogaster as a part of the Genome Annotation Assessment Project (GASP). Predictions from three versions of the Genie gene-finding system were submitted, one based on statistical properties of coding genes, a second included EST alignment information, and a third that integrated pr...

The GENIE project has built a Grid enabled framework that facilitates the integration, execution and management of component models for the study of the Earth system over millennial timescales. The existing framework supports collaborative study of GENIE models across heterogeneous compute grids through scripted workflows in the Matlab environment. In this paper, Windows Workflow Foundation tec...

In this paper, we consider the problem of learning the genetic interaction map, i.e., the topology of a directed acyclic graph (DAG) of genetic interactions from noisy double-knockout (DK) data. Based on a set of well-established biological interaction models, we detect and classify the interactions between genes. We propose a novel linear integer optimization program called the Genetic-Interac...

Decision support systems can play a role in improving the ability of decision makers to act as utility maximizers in crisis situations. This paper demonstrates the ability of one such decision support system, GENIE, to help decision makers maximize their objectives in a crisis negotiation. GENIE is described in detail, followed by the presentation of preliminary experimental results evaluating ...

UNLABELLED GENIE implements a statistical framework for inferring the demographic history of a population from phylogenies that have been reconstructed from sampled DNA sequences. The methods are based on population genetic models known collectively as coalescent theory. AVAILABILITY GENIE is available from http://evolve.zoo.ox.ac.uk. All popular operating systems are supported.