Background:Ghrelin, an endogenous ligand for the growthsecretagogue receptor is predominantly produced in the stomach and anexpression of ghrelin has recently been identified in placenta and ovary. OBJECTIVES: Therefore, we decited to measure ovarian ghrelin as quantitative andevaluate the correlation between ghrelin and estrogen during second half ofovine pregnancy. METHODS: The ovarian sample...

ghrelin increases food intakes and body weight. bombesin decreases food intakes and inhibits the stimulatory effect of ghrelin on food intakes. thyroid hormones have a crucial role in the regulation of body weight and yet the effect of bombesin on thyroid axis activity is not fully clear. therefore, the goal of this study was to determine the effect of different doses of ghrelin or bombesin on ...

ghrelin, a peptide hormone, has several functions, of which the best known is its growth hormone (gh)-releasing effect in the pituitary. it also increases appetite and feeding behavior. recent studies have implicated ghrelin in the regulation of gastrointestinal, cardiovascular, and immune function, and suggest a role for ghrelin in bone physiology. in this study, the effect of chronically admi...

background: the hormones of hypothalamo-pituitary-gonadal (hpg) axis have facilitative effects on reproductive behavior in mammals. ghrelin as a starvation hormone has an inhibitory effect on hpg axis’ function. hence, it is postulated that ghrelin may reduce the sexual behavior through inhibiting of hpg axis. the aim of this study was to examine the effects of ghrelin and its antagonist, [d-ly...

Ghrelin increases food intakes and body weight. Bombesin decreases food intakes and inhibits the stimulatory effect of Ghrelin on food intakes. Thyroid hormones have a crucial role in the regulation of body weight and yet the effect of bombesin on thyroid axis activity is not fully clear. Therefore, the goal of this study was to determine the effect of different doses of Ghrelin or bombesin on ...

Acyl ghrelin has a 28-amino acid sequence with O-n-octanoyl acid modification at the serine 3 position, whereas des-acyl ghrelin has no octanoyl acid modification. Although these peptides exert different physiological functions, no previous studies have shown the different localization of acyl ghrelin and des-acyl ghrelin in the stomach. Here we have developed an antibody specific for des-acyl ...

Ghrelin, a peptide hormone, has several functions, of which the best known is its growth hormone (GH)-releasing effect in the pituitary. It also increases appetite and feeding behavior. Recent studies have implicated ghrelin in the regulation of gastrointestinal, cardiovascular, and immune function, and suggest a role for ghrelin in bone physiology. In this study, the effect of chronically admi...

The gut hormone ghrelin is widely beneficial in many disease states. However, ghrelin exists in two distinctive isoforms, each with its own metabolic profile. In Parkinson's Disease (PD) acylated ghrelin administration is neuroprotective, however, the role of des-acylated ghrelin remains unknown. In this study, we wanted to identify the relative contribution each isoform plays using the MPTP mo...

To elucidate the role of endogenous ghrelin in the regulation of energy homeostasis and gastric emptying, ghrelin knockout mice (ghrelin(-/-)) were generated. Body weight, food intake, respiratory quotient, and heat production (indirect calorimetry), and gastric emptying ((14)C breath test) were compared between ghrelin(+/+) and ghrelin(-/-) mice. In both strains, the effect of exogenous ghreli...