A 27-year-old man treated 2.5 years ago for synchronous multicentric giant cell tumor of bone located at the right proximal humerus and the right 5th finger presented now with complaints of pain in his right hip and wrist of two-month duration. Radiology and magnetic resonance revealed multicentric giant cell tumor lesions of the right proximal femur, the left ileum, the right distal radius, an...

Both giant synovial osteochondroma and parosteal osteosarcoma are rare musculo-skeletal tumors, often localized in the vicinity of the knee. Misdiagnosis of a malignant bone tumor can entail fatal consequences. Etiology of giant synovial osteochondroma is widely unsolved but is believed to originate from synovial chondromatosis, a mostly benign metaplasia of the synovial membrane. Parosteal ost...

This report discusses a rare case of giant cell-rich osteosarcoma. The patient, a 19-year-old male, was diagnosed with a metadiaphyseal osteolytic lesion when he consulted a local doctor complaining of motion pain without swelling. Radiography revealed a geographic osteolytic lesion, cortical thinning and ballooning without obvious cortical destruction. However, a fine onion skin-like periostea...

giant cell glioblastoma is an extremely rare variant of glioblastoma (who grade iv) which is characterized by a predominance of bizarre, multinucleated giant cells. these tumors comprise of 0.8% of brain tumors and up to 5% of glioblastomas. in pediatric age group, these tumors are still uncommon with only around 53 published cases since 1952. here, we report a case of a 12-year old female pati...

giant cell tumors (gct) are benign tumors with potential for aggressive behavior and capacity to metastasize. although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. its histogenesis remains unclear. it is characterized by a proliferation of mononuclear stromal ce...

Osteosarcoma (OS) is a common primary malignant tumor of bones that produces osteoid matrix. Telangiectatic osteosarcoma (TOS) is a rare variant of OS. It affects the long bones especially the lower end of femur and the upper ends of tibia and humerus, a distribution similar to the conventional osteosarcoma. The rib involvement is very infrequent. We present a case of TOS of the rib that posed ...

background and aims. the correlation between morphology of giant cells in peripheral granulomas of the jaws and the aggressive behavior of the lesion is unknown. this study investigated the correlation between the histopathologic features with demographic, gross and radiographic findings in giant cell granulomas. materials and methods. in this analytical study, data from 23 cases of central gia...