Glioblastoma multiform is a primary brain tumor derived from glial cells. The aim of this study to investigate how glutamate metabolism regulated by transporter 1 (GLT-1) degradation pathway in glioblastoma and cell lines. protein expression levels GLT-1, total ubiquitin, kinase C (PKC) proteins involved the GLT-1 were measured western blot technique. Additionally, cells, level accumulated medi...

primary and secondary malignant central nervous system (cns) tumors are devastating invasive tumors able to give rise to many kinds of differentiated tumor cells. glioblastoma multiform (gbm), is the most malignant brain tumor, in which its growth and persistence depend on cancer stem cells with enhanced dna damage repair program that also induces recurrence and resists current chemo- and radio...

Introduction: Glioblastoma multiforme (GBM) is a highly radioresistant cancer with low survival rate. Current therapy approaches have failed to treat GBM. The aim of this study was to assess how GBM tumors respond to combination of hyperthermia and radiotherapy. Materials and Methods:   In this study, 38 GBM patients were included. 19 patients were treated ...

Abstract Background Glioblastoma multiform is the most common and aggressive type of primary malignant tumor that affects central nervous system in adults. It clinically presents with seizures, headache, and/or progressive focal neurological deficits. Radiologically, glioblastoma appears as a single distinguishable, large heterogeneous lesion affecting cerebrum characteristic necrosis, marginal...

Glioblastoma multiform (GBM) is the most common and lethal type of primary brain tumors with high rates of morbidity and mortality. Treatment options are limited and ineffective in most of the cases. Epidemiological studies have shown a link between inflammation and glioma genesis.  In addition, at the molecular level, pro-inflammatory cytokines released from activated microglia can increa...