Tumor cells rely preferentially on anaerobic glycolysis rather than on respiration for ATP generation, a phenomenon known as the Warburg effect. We explored the effects of glucose withdrawal on glioblastoma multiforme-derived cell lines and their nontransformed counterparts, normal human astrocytes. We found that glucose withdrawal induces extensive apoptosis in glioblastoma multiforme cells bu...

Glioblastoma multiforme is an aggressive, treatment-refractory type of brain tumor for which effective therapeutic targets remain important to identify. Here, we report that cyclophilin B (CypB), a prolyl isomerase residing in the endoplasmic reticulum (ER), provides an essential survival signal in glioblastoma multiforme cells. Analysis of gene expression databases revealed that CypB is upregu...

background: high-grade astrocytoma (grade 4) or glioblastoma multiforme (gbm) are deadly brain tumors. new therapies attempt to increase lifetime and quality of life in patients with malignant astrocytoma. o6-methylguanine-dna methyltransferase (mgmt) enzyme expression may be effective in prognosis and response to treatment of these patients. the aim of this study was assessment of mgmt enzyme ...

gliobalstoma multiforme (gbm) or grade 4 astrocytoma is the most malignant form of primary brain tumor. treatment of glioblastoma is difficult despite of surgery, radiotherapy and chemotherapy. patients with glioblastoma survive for less than 12 months. considering to biology function of glioblastoma, researchers have recently offered new therapeutic approaches such as cannabinoid therapy for g...

Glioblastoma multiforme is an aggressive, treatment-refractory type of brain tumor for which effective therapeutic targets remain important to identify. Here, we report that cyclophilin B (CypB), a prolyl isomerase residing in the endoplasmic reticulum (ER), provides an essential survival signal in glioblastoma multiforme cells. Analysis of gene expression databases revealed that CypB is upregu...

BACKGROUND Glioblastoma multiforme (GBM) is an invariably fatal central nervous system tumor despite treatment with surgery, radiation, and chemotherapy. Further insights into the molecular and cellular mechanisms that drive GBM formation are required to improve patient outcome. MicroRNAs are emerging as important regulators of cellular differentiation and proliferation, and have been implicate...

Glioblastoma multiforme is a central nervous system tumor of grade IV histological malignancy according to the WHO classification. Over 90% of diagnosed glioblastomas multiforme cases are primary gliomas, arising from normal glial cells through multistep oncogenesis. The remaining 10% are secondary gliomas originating from tumors of lower grade. These tumors expand distinctly more slowly. Altho...

Cerebellar Glioblastoma Multiforme is a rare condition, a review of the world literature and two further cases are presented. Cerebellum, glioblastoma multiforme, surgery, radiotherapy.

Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor, accounting for 52% of all primary brain tumor cases and 20% of all intracranial tumors. Recently, evidence for a viral cause has been postulated, possibly cytomegalovirus (CMV). In one report, 80% of patients with newly diagnosed glioblastoma multiforme had detectable cytomegalovirus DNA in their periphe...

A new gold( i )-based therapeutic strategy to treat glioblastoma multiforme (GBM).