how to cite this article: yaghini o, kelishadi r, keikha m, niknam n, sadeghi s, najafpour e, ghazavi mr. prevalence of developmental delay in apparently normal preschool children in isfahan, central iran. iran j child neurol. summer 2015;9(3):17-23. abstract objective developmental delay screening is essential in pediatric medicine. the purpose of this study was to estimate the developmental d...

INTRODUCTION Global developmental delay (GDD) affects 1%-3% of the population of children under 5 years of age, making it one of the most common conditions presenting in paediatric clinics; causes are exogenous, genetic (non-metabolic) or genetic (metabolic). Recent advances in biotechnology and genetic testing mean that the investigations available to perform for children under 5 years are inc...

The FOXP protein family (FOXP1-4) is a group of transcription factors that play important roles in embryological, immunological, hematological, and speech and language development. Here, we report FOXP1 de novo mutation and severe speech delay in an individual belonging to a non-Caucasian population.

The investigation of global developmental delay in preschool children varies between centres and between paediatricians. Following a literature search and review of the evidence base, guidelines were developed to assist in the assessment and management of such children presenting to secondary level services. Evidence supporting the use of genetic and biochemical investigations on a screening ba...

The three-spined stickleback Gasterosteus aculeatus is an important model for studying microevolution and parallel adaptation to freshwater environments. Marine and freshwater forms differ markedly in their phenotype, especially in the number of lateral plates, which are serially repeated elements of the exoskeleton. In fishes, thyroid hormones are involved in adaptation to salinity, as well as...

BACKGROUND Although several determinants of global developmental delay (GDD) have been recognized, a significant number of children remain without definitive etiologic diagnosis. The objective of this study was to assess the effect of various prenatal and perinatal factors on the severity and outcome of developmental delay without definitive etiologic yield. METHODS From March 2008 to Februar...

Children with retarded development of visual perception were compared with previously tested normal children Verbal and non-verbal patterns were presented either to the left or to the right hemisphere. In both groups of children the results showed a functional equality of the hemispheres during analysis of the non-verbal patterns. Left hemisphere superiority for verbal material in Normal group ...

proposed. The model is based on transfer of performance methodology. A series of the experimental studies investigate the viability of a hierarchical model for two levels of difficulties for tasks identifiable with the Control Precision and Rate Control factors. The results are inconclusive regarding the concept of a hierarchical earning for psychomotor skills. The results indicate that substan...

The chromosome 22q11.2 region has long been implicated in genomic diseases. Some genomic regions exhibit numerous low copy repeats with high identity in which they provide increased genomic instability and mediate deletions and duplications in many disorders. DiGeorge Syndrome is the most common deletion syndrome and reciprocal duplications could be occurring in half of the frequency of microde...

OBJECTIVE To examine the decisions of pediatric primary care physicians about their diagnostic evaluation for a child with suspected global developmental delay (GDD). STUDY DESIGN A survey was mailed to a sample of pediatricians (n = 600) and family physicians (n = 600) randomly selected from the American Medical Association Physician Masterfile. The survey contained a clinical vignette descr...