oxygen free radicals may be implicated in the pathogenesis of ischemia reperfusion damage. as the antioxidant effects of some species of pistacia have been reported, the protective effects of pistacia vera l. gum extract (0.1-0.5 g/kg) on oxidative damage following cerebral ischemia were studied in rats. ischemia was induced using four-vessel occlusion model and evaluated using measurement of m...

objective(s): global cerebral ischemia-reperfusion (gcir) causes disturbances in brain functions as well as other organs such as kidney. our aim was to evaluate the protective effects of ellagic acid (ea) on certain renal disfunction after gcir. materials and methods: adult male wistar rats (n=32, 250-300 g) were used. gcir was induced by bilateral vertebral and common carotid arteries occlusio...

objective(s) the brief interruption of cerebral blood flow causes permanent brain damage and behavioral dysfunction. the hippocampus is highly vulnerable to ischemic insults, particularly the ca1 pyramidal cell layer. there is no effective pharmacological strategy for improving brain tissue damage induced by cerebral ischemia. previous studies reported that pentoxifylline (ptx) has a neuroprote...

Objective(s): Morphine dependence (MD) potently protects heart against ischemia reperfusion (IR) injury through specific signaling mechanisms, which are different from the pathways involved in acute morphine treatment or classical preconditioning. Since opioid receptor density changes post cerebral ischemia strongly correlated with brain histological damage, in the present study, we tried to el...

conclusions the analysis of the pro-apoptotic gene to anti-apoptotic gene expression ratio (bad /bcl-xl) confirmed that expression of the pro-apoptotic gene significantly decreased (p value ˂ 0.001) under the ischemia/reperfusion condition. in contrast, the expression of the anti-apoptotic gene increased after administration of fk-506 (p value ˂ 0.001). results the quantitative results of real-...

Introduction: Nucleobinding-2 (NUCB2) or nesfatin-1, a newly identified anorexigenic peptide, has antioxidant, anti-inflammatory, and anti-apoptotic properties. Brain ischemia-reperfusion induces irreversible damages, especially in the hippocampus area. However, the therapeutic effects of NUCB2 have not been well investigated in cerebral ischemia. This study was designed for the first time to i...

global myocardial ischemia and ischemia-reperfusion injury are potential adverse events related with cardioplegic arrest. beating heart surgery has avoided such complications and adapted to valve surgery following successful results published on myocardial revascularization. difficulty in weaning from cardiopulmonary bypass may be lessened by using on-pump beating heart surgery for mitral valve...

background: it has been reported that the chronic oral administration of garlic homogenate protected the rat heart from in vitro ischemic reperfusion injury. however, the biological effects of garlic juice on the heart are expected to be different from oral administration of it. objective: the present study was designed to investigate the effect of garlic juice on the isolated rat heart in isch...

Objective(s): Obestatin is a newly discovered peptide with antioxidant activities in different animal models. Recent studies have shown that Obestatin inhibits apoptosis following cardiac ischemia/reperfusion injury. Brain ischemia/reperfusion induces irreversible damage especially in the hippocampus area. This study aimed at examining the protective impact of Obestati...