Hemodialysis (HD) is the most frequently used treatment for end-stage renal disease. Despite all efforts to improve the outcomes, the mortality of patients on HD is still high, and this is especially related to cardiovascular diseases (CVD). Glucose degradation products accumulate in plasma and tissue; such accumulation is strongly related to the risk of developing CVD. Tissue deposits of advan...

During the standard heat sterilization process of the lactate-buffered peritoneal dialysis solutions, glucose (an osmotic active substance) degrades to form compounds called glucose degradation products which are cytotoxic and affect the survival of the peritoneal membrane. This case presentation is based on an observation of 224 aseptic peritonitis cases of unknown etiology. For the purpose of...

Minimally invasive desorption electrospray ionization-mass spectrometry (DESI-MS) and laser ablation electrospray ionization-MS (LAESI-MS) were used to look for soluble cellulose degradation products produced by accelerated aging in unsized cotton paper. Soluble extracts from papers aged 144 to 26,856 hours were first analyzed in solution using traditional electrospray ionization-MS (ESI-MS). R...

This review paper describes methods of protecting the peritoneal membrane in uremic patients chronically treated with peritoneal dialysis. Possible interventions involved in protection of the peritoneum aim at reducing peritoneal exposure to glucose, glucose degradation products and lactate; preventing or diminishing harmful effects of dialysis solutions; decreasing infection rate, especially p...

BACKGROUND The mesothelium contributes significantly to the functional, structural and homeostatic properties of the peritoneum. Bioincompatible peritoneal dialysis solutions contribute to mesothelial cell loss during chronic peritoneal dialysis. Cell death has been implicated in mesothelial cell loss, but the molecular mechanisms have not been adequately characterized. We now report the modula...