objective: since bread is the main source of food in iran, we aimed to assess the effect of four types of iranian breads on metabolic and cardiovascular responses before and during 15, 30, 60, 90, 120 and 180 minutes of consumption in type 2 diabetic patients. materials and methods: ten type 2 diabetic patients (6 women and 4 men) with mean age of 51 ± 9.8 years and mean bmi of 31.9 ± 1.19 kg/m...

background: considering that serum gamma-glutamyl transferase (ggt) activity could reflect several different processes relevant to diabetes pathogenesis and the increasing rate of type 2 diabetes worldwide, the aim of this study was to assess the association between serum ggt concentrations and glucose intolerance, in the first-degree relatives (fdr) of type 2 diabetic patients. methods: in thi...

Sodium–glucose co transporter 2 (SGLT2) inhibitors decrease glycated hemoglobin levels and have shown favorable effects on kidney cardiovascular outcomes in large clinical trials involving patients with type diabetes. This hemodynamic effect may also preserve function persons diseases due to causes other than

Dapagliflozin is a sodium-glucose co-transporter-2 (SGLT2) inhibitors used in the treatment of patients with type 2 diabetes. An aryl glycoside significant effect as glucose-lowering agents, also has indication for Heart Failure and Chronic Kidney Disease. This review examines structure, synthesis, analysis, structure activity relationship uses product. The studies behind this drug have opened ...

We describe an implemented model of glucose absorption in the enterocyte, as previously published by Afshar et al. (2019), The used mechanistic descriptions all responsible transporters and was built CellML framework. It validated against experimental data a modular structure which allows each individual transporter to be edited independently from other transport protein models. composite then ...

The efficacy of the administration of sodium-glucose co-transporter 2 inhibitor or the co-administration of sodium-glucose co-transporter 2 inhibitor and dipeptidyl peptidase-4 inhibitor to insulin therapy is not well known. A total of 58 patients with type 2 diabetes, admitted for glycemic control, were randomized to basal-bolus insulin therapy (BBT) alone or BBT plus 50 mg ipragliflozin and/o...

Background: Previous studies have suggested benefits of sodium glucose co-transporter 2 (SGLT2) inhibitors including improving glycemic control, lower body weight, uric acid-lowering effect and decreasing blood pressure. The aim this study was to evaluate the effects SGLT2 on hematocrit (Hct) levels in patients with type diabetes mellitus.

The transport of glucose across the plasma membrane is mediated by members of the glucose transporter family. In this study, we investigated glucose uptake through the yeast hexose transporter 1 (Hxt1) by measuring incorporation of 2-NBDG, a non-metabolizable, fluorescent glucose analog, into the yeast Saccharomyces cerevisiae. We find that 2-NBDG is not incorporated into the hxt null strain la...

A life-saving response to hypoglycemia requires rapid sensing of decreases in glycemia and consequent brisk glucagon secretion. Preceding studies have shown that mice lacking glucose transporter type 2 (GLUT2) lose this response. In this issue of the JCI, Marty et al. report that glucose sensing and consequent pancreatic glucagon secretion are restored by re-expression of GLUT2 in glial but not...