نتایج جستجو برای: glutaryl coa
تعداد نتایج: 26089 فیلتر نتایج به سال:
BACKGROUND The prevalence and risk of cardiovascular disease increase after menopause in correlation with the progression of abnormality in the serum lipid profile and the deprivation of estrogen. Erxian decoction (EXD), a Chinese medicinal formulation for treating menopausal syndrome, stimulates ovarian estrogen biosynthesis. This study investigates whether EXD improves the serum lipid profile...
Statins were recently shown to possess anti-inflammatory activities, which might be responsible for their favourable effects in cardiovascular or CNS disorders independently from the inhibition of hydroxy-methyl-glutaryl CoA reductase. Here we investigated the effects of the statins lovastatin and mevastatin on prostanoid production in primary cultures of rat cortical microglia and astrocytes. ...
Several different enzymes have been described which catalyze hydrolysis of acyl CoA derivatives. Acetyl CoA deacylase z, and succinyl CoA deacylase z-4, hydroxyisobutyryl CoA deaeylase ~ and a hydroxymethyl glutaryl CoA deacylase 6 have been described. Enzyme preparations that deacylate acetoacetyl CoA have been described~, 8 but recent evidence points to a more involved mechanism than one of s...
The activity of acetoacetyl-CoA (AcAc-CoA) ligase (E.C.6.2.1.16) in hepatocytes from rats was shown to be the same as the activity in homogenates of their livers. In hepatocytes treated with 25-hydroxycholesterol, AcAc-CoA ligase, 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase and rates of sterol synthesis were substantially decreased. Hepatocytes treated with high density lipoprotein (HDL...
ante by carboxylic acid would result if the equilibrium of Reaction 3 were significantly toward R(CHz), CO-S-CoA or if the latter disappeared in secondary reactions. In practice, acetylCoA was incubated with enzyme fractions with and without added carboxylic acids under the conditions described in Table I. At the end of the incubation period, 0.1 volume of 30% metaphosphoric acid was added, the...
Leoligin, the Major Lignan from Edelweiss, Inhibits 3-hydroxy-3-methyl-glutaryl-CoA Reductase and Reduces Cholesterol Levels in ApoE -/mice Short title: Leoligin – a new cholesterol-lowering drug Bernhard Scharinger, Barbara Messner, Adrian Türkcan, Daniela Schuster, Anna Vuorinen, Florian Pitterl, Katharina Heinz, Kathrin Arnhard, Günther Laufer, Michael Grimm, Hermann Stuppner, Herbert Oberac...
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