The complex antioxidant network of plant and animal cells has the thiol tripeptide GSH at its centre to buffer ROS (reactive oxygen species) and facilitate cellular redox signalling which controls growth, development and defence. GSH is found in nearly every compartment of the cell, including the nucleus. Transport between the different intracellular compartments is pivotal to the regulation of...

Many functions have been ascribed to glutathione, a tripeptide that has been known for almost a century.* Glutathione is found in virtually all mammalian cells, usually in substantial concentrations (0.510 mM). The concentration of glutathione in extracellular fluids such as blood plasma is in the micromolar range. The intracellular concentration of glutathione exceeds by far that of glutathion...

introduction: the fate of xenobiotics that is present, increasing day by day. the increasing fates altered or inhibit the metabolic activities like detoxification and biotransformation. methods: the present study highlights this slow biotransformation and detoxification on the basis of specific enzymes which have a say in assessment of mercuric chloride toxicity and modulation by panax ginseng ...

  Heavy metals are the cause of major abiotic stresses in plants and a principal contributor to environmental pollution in recent decades. This study investigated the effects of exogenous hydrogen sulfide on the ascorbate-glutathione cycle in the leaves of coriander seedlings under copper stress. Results showed that copper stress not only reduced APX and GR activities but also decreas...

Background: Glutathione S-transferases (GSTs) are detoxifying enzymes that contribute to the glutathione-ascorbic acid (vitamin C) antioxidant cycle. Objective: The objective was to determine whether GST genotypes modify the association between dietary vitamin C and serum ascor-

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In this study, the effect of vitamin B3 supplement given to rats was investigated on glutathione redox cycle by looking at peroxidase and s transferase activities. 20 Wistar albino male were used. Vitamin one two groups that formed. The other group determined as control group. 360 mg/kg/day oral gavage method for 10 days. At end days, intracardiac blood samples taken. Glutathione activity level...

BACKGROUND Glutathione has a wide range of functions; it is an endogenous anti-oxidant and plays a key role in the maintenance of intracellular redox balance and detoxification of xenobiotics. Several studies have indicated that children with autism spectrum disorders may have altered glutathione metabolism which could play a key role in the condition. METHODS A systematic literature review a...