Heat extraction mode, e.g. well layout or arrangement of wells, of enhanced or engineered geothermal system (EGS) is crucial to its performance and directly affects its commercial viability. Assuming the subsurface target hot dry rock (HDR) has been well-fractured and the created heat reservoir can be treated as a homogeneous porous medium, we numerically simulate the long-term heat extraction ...

The pathogenesis of equine grass sickness (EGS) has not fully understood. A better understanding of the exact pathogenesis of diseases can help to make an accurate diagnosis. Previous studies reported some pathological damage of neuronal cells in EGS patients. In this study, primarily cytotoxicity of serum from three clinically EGS-diagnosed horses on PC12 Tet-off (PTO) cells was assessed. Subs...

Autism spectrum disorder (ASD) is a heterogeneous, highly heritable neurodevelopmental syndrome characterized by impaired social interaction, communication, and repetitive behavior. It is estimated that hundreds of genes contribute to ASD. We asked if genes with a strong effect on survival and fitness contribute to ASD risk. Human orthologs of genes with an essential role in pre- and postnatal ...

Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good water-solubility and biocompatibility. However, there has not been an explicit description of applying EGs as a vehicle for hypertrophic scars treatment. Here, a novel transdermal EGs loaded with 5-fluorouracil (5-FU EGs) was successfully prepared and characterized. The stab...

the pathogenesis of equine grass sickness (egs) has not fully understood. a better understanding of the exact pathogenesis of diseases can help to make an accurate diagnosis. previous studies reported some pathological damage of neuronal cells in egs patients. in this study, primarily cytotoxicity of serum from three clinically egs-diagnosed horses on pc12 tet-off (pto) cells was assessed. subs...

Surveillance Equine grass sickness (EGS, equine dysautonomia) remains a frequently fatal polyneuropathy of equids. The Animal Health Trust (AHT) continues to host a nationwide surveillance scheme (http://www.equinegrasssickness.co.uk/), in which data from 1410 EGS cases, collated for the decade 2000-2009, were published previously [1]. Since 2010 a further 642 EGS cases have been reported to th...

BACKGROUND Equine dysautonomia or equine grass sickness (EGS), as it is more commonly known, is a usually fatal disease of equids of uncertain etiology, although associated with grazing, that affects the autonomic and enteric nervous system. Lowered gastrointestinal motility, leading to paralysis of the gut, is one of the main symptoms of EGS. Previous studies have implicated anaerobic bacteria...

External guide sequence (EGS) RNAs are associated with ribonuclease P (RNase P), a tRNA processing enzyme, and represent promising agents for gene-targeting applications as they can direct RNase-P-mediated cleavage of a target mRNA. Using murine cytomegalovirus (MCMV) as a model system, we examined the antiviral effects of an EGS variant, which was engineered using in vitro selection procedures...

REASONS FOR PERFORMING STUDY Equine grass sickness (EGS) remains a frequently fatal disease of equids in Britain. Since previous investigations of signalment- and meteorology-related risk factors for EGS have yielded some conflicting data, further investigation is warranted. OBJECTIVES To identify signalment- and meteorology-related risk factors for EGS in Scotland. STUDY DESIGN Retrospecti...

The widely renowned M.I.T. study “The Future of Geothermal Energy” (2006) determined recoverable EGS resources > 200,000 EJ alone for the USA, corresponding to 2,000 times the annual primary energy demand. To universally and globally utilize these immense resources exciting R&D problems need to be tackled: 1) Development of a technology to produce electricity and/or heat from a basically ubiqui...