metronidazole and its derivatives have both antiprotozoal and anti bacterial effects. the reproductive toxicity of metronidazole has been observed in some studies. the aim of this study was to determine the detrimental effects of metronidazole on spermatogenesis and testicular androgenesis in male adult rats. eighteen male wistar rats (70-90 days old) were randomly divided into three groups. an...

-Gonadotrophins, oestradiol, androstenedione, testosterone and dehydroepiandrosterone sulphate (DHAS) were measured sequentially in 72 patients with advanced breast cancer receiving endocrine therapy of various types. Tamoxifen significantly reduced gonadotrophins but did not effect other hormones. Danazol also reduced gonadotrophins. Aminoglutethimide (AGT) reduced oestradiol and DHAS but had ...

Achieving ovulation in women with Kallmann's syndrome requires both exogenous FSH and LH to successfully stimulate follicular maturation and ovarian steroidogenesis. We present a case of a woman with Kallmann's syndrome, who had poor ovarian response to stimulation by exogenous gonadotrophins. When she was given testosterone by patch before initiation of gonadotrophins, her stimulation dramatic...

Until recently there has been fairly general agreement that gonadotrophins are not detectable in the urine during childhood. Table I summarizes the results of previous investigators in this field. Of the early workers, only Catchpole and Greulich (1943) have, in serial determinations, detected gonadotrophins in young girls. More recently, studies performed on pools of urine have indicated that ...

Background Polycystic ovary syndrome (PCOS) is a common and complex condition affecting up to 18% of reproductive-aged women with reproductive, metabolic and psychological dysfunction. We performed an overview and appraisal of methodological quality of systematic reviews assessing medical and surgical treatments for reproductive outcomes in women with PCOS. Methods This was an overview of syste...

The aim of this study was to examine the effect of thyroxine on ovulation in immature rdw rats and the fertilization and development of the eggs. Serum thyroxine concentrations at 30 days of age were significantly lower in rdw rats than in normal rats (P < 0.001), and greatly increased after thyroxine replacement therapy (P < 0.001). Although few eggs (1-5 +/- 1-2) were obtained from immature r...