Alex McMahon and colleagues critique the International Conference on Harmonisation (ICH) guidance on good clinical practice (GCP), arguing that it is having a disastrous effect on noncommerical randomized clinical trials in Europe.

The fallacy of the popular concept that "it's good enough for clinical purposes" is becoming more widely recognized as the potentialities of scientific methods in diagnosis and therapy increase. Such a manual as this should aim to raise the dignity and improve the quality of clinical chemistry and clinical chemists, not, by conceding to prevailing opinion, perpetuate its present mediocre estate...

1 Ethno Medicines of Kolli Hills at Namakkal District in Tamilnadu and its significance in Indian Systems of Medicine G.Arunachalam, M.Karunanithi N.Subramanian, V.Ravichandran and S.Selvamuthukumar PGP College of Pharmaceutical Science and Research Institute, NH -7, Namakkal Karur Main Road, Namakkal – 637297, Tamilnadu, India. Department of CARISM, SASTRA University, Thanjavur 613402, Tamilna...

The design of a complex regulator often includes the making of a model of the system to be regulated. The making of such a model has hitherto been regarded as optional, as merely one of many possible ways. m this paper a theorem is presented which shows, under very broad conditions, that any regulator that is maximally both successful and simple must be isomorphic with the system being regulate...

Since the early 1980s, the research community has developed ever more sophisticated algorithms for the problem of energy disaggregation, but despite decades of research, there is still a dearth of applications with demonstrated value. In this work, we explore a question that is highly pertinent to this research community: how good does energy disaggregation need to be in order to infer characte...

Seit mehr als einem Jahrzehnt gilt das Programm PGP („Pretty Good Privacy“) als der Standard für E-Mailund Datei-Verschlüsselung, insbesondere unter Internet-Benutzern. Seit der ersten Version der Software hat sich jedoch vieles verändert. Im vergangenen Jahr äußerten die beiden Autoren ihre Sorge um die Zukunft von PGP. An dieser Stelle aus aktuellem Anlass ein Update, denn seit der Heise News...

The treatment of Chagas disease is limited by the frequent cutaneous side effects of benznidazole. We tested the use of steroids plus escalating doses of benznidazole to prevent this complication in 17 adult patients with chronic Trypanosoma cruzi infection and found extremely good tolerance. A randomized trial is warranted.