over production of uric acid by xanthine oxidase (xo) causes gout. xo inhibitors for example allopurinol are the most important available anti gout drugs. medicinal herbs are available natural sources that may be useful for the treatment of gout. in this study the inhibitory activity of aqueous extracts of matricaria chamomilla l., hypericum perforatum l., fraxinus excelsior l., zea mays l., tr...

Background/Aims We performed this study to investigate associations between metabolic syndrome, chronic kidney disease (CKD), and gout. Methods We reviewed the medical records of 151 patients with gout at the Department of Rheumatology in Korea University Ansan Hospital. The following measures were examined: waist circumference, blood pressure, alcohol consumption, and levels of triglyceride,...

OBJECTIVE To examine and quantify the relation between purine intake and the risk of recurrent gout attacks among gout patients. METHODS The authors conducted a case-crossover study to examine associations of a set of putative risk factors with recurrent gout attacks. Individuals with gout were prospectively recruited and followed online for 1 year. Participants were asked about the following...

OBJECTIVE To assess the impact of gout on health-related quality of life (HRQoL) among patients in three large US cities. METHODS Gout patients completed the Short Form-36 (SF-36) and a series of questions regarding their gout, comorbidities and demographics. Their physicians confirmed the gout diagnosis and evaluated the severity of patient's gout. The differences in mean norm-based SF-36 sc...

OBJECTIVE To describe a group of patients with frequent tophaceous gout, the variables associated with severe tophaceous gout and to compare them with other patients with gout described elsewhere. METHODS We looked for 65 demographic clinical and paraclinical variables from patients with gout who attended our gout clinic from 1995-2000 and were evaluated by the same group of physicians. RES...

Gout is the most common crystal arthropathy and the leading cause of inflammatory arthritis. It is associated with functional impairment and, for many, a diminished health-related quality of life. Numerous studies have demonstrated the impact of gout and its associated conditions on patient morbidity and mortality. Unfortunately, gout remains under-diagnosed and under-treated in the general com...

INTRODUCTION There is a growing prevalence of gout in the US and worldwide. Gout is a recognized risk factor for cardiovascular disease (CVD). It is unclear whether other risk factors for CVD are also associated with increased risk of gout. Anemia is one such CVD risk factor. No studies have evaluated the relationship between anemia and gout. We tested whether anemia was associated with inciden...

The pathophysiology of gout is well understood, and effective treatments for acute gout and hyperuricemia leading to gout are widely available. Nonetheless, many patients suffer from severe tophaceous gouty arthritis, adverse effects of medications for gout, and inadequate treatment of hyperuricemia. The incidence of gout is rising in both men and women. The diagnosis and treatment of gout are ...

OBJECTIVES To investigate if serum Lp(a) lipoprotein (Lp(a)), a risk factor for atherosclerotic diseases, increases in patients with gout, who frequently also have atherosclerotic disease. METHODS Fasting blood samples were taken for measurement of Lp(a) and other variables in 175 male patients with primary gout. Serum concentrations of Lp(a) were measured by enzyme linked immunosorbent assay...

Background Gout is on the increase worldwide and is the most common form of inflammatory arthritis affecting men. Gout is of particular significance to New Zealand, affecting approximately 15% of Maori and Pacific men in South Auckland, thus it has been dubbed the ‘gout capital of the world’. Gout most frequently affects the foot, with initial attack affecting in the first metatarsophalangeal j...