Background and objectives: Coumarins have potential anticancer effects. Ferulago macrocarpa (Fenzl) Boiss, is a perennial herb which has shown to have several dihydropyranocoumarins like grandivittin (GRA) and dihydrofuranocoumarins such as prantschimgin (PRA). Previously the antibacterial, cytotoxic and antioxidant effect of GRA and PRA have been reported. Understandi...

We propose the following principle to study pointed Hopf algebras, or more generally, Hopf algebras whose coradical is a Hopf subalgebra. Given such a Hopf algebra A, consider its coradical filtration and the associated graded coalgebra grA. Then grA is a graded Hopf algebra, since the coradical A0 of A is a Hopf subalgebra. In addition, there is a projection π : grA → A0; let R be the algebra ...

Toxoplasma gondii actively invades host cells and establishes a parasitophorous vacuole (PV) that accumulates many proteins secreted by the dense granules (GRA proteins). To date, at least 23 GRA proteins have been reported, though the function(s) of most of these proteins still remains unknown. We targeted gene knockouts at ten GRA gene loci (GRA1-10) to investigate the cellular roles and esse...

We earlier showed that 18β-glycyrrhetinic acid (GRA), a pentacyclic triterpenoid from licorice root, could completely cure visceral leishmaniasis in BALB/c mouse model. This was associated with induction of nitric oxide and proinflammatory cytokine production through the up regulation of NF-κB. In the present study we tried to decipher the underlying cellular mechanisms of the curative effect o...

Granzyme A (GrA) and B (GrB) together with perforin are the main constituents of cytotoxic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. The cytotoxic proteins are released to deliver a lethal hit during contact between the CTL or NK cell and target cell. With the use of an enzyme-linked immunosorbent assay for antigenic levels, we showed in a recent study that plasm...

Glucocorticoid-remediable aldosteronism (GRA) is a hereditary form of primary hyperaldosteronism that presents with hypokalemia and hypertension from childhood onward. GRA is characterized by the ectopic production of aldosterone in the cortisol-producing zona fasciculata under the regulation of adrenocorticotrophic hormone. Despite the early age of onset, no previous reports of pregnancy and G...

The research scope of grey relational analysis has not been developed in recent years, and the exiting GRA models are all based on three perspectives, including distance perspective, slope perspective, and area perspective. Under this situation, a novel model called grey relational analysis based on angle perspective (GRAAP) was developed in this paper for the first time, and this model can exp...

The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Granisetron hydrochloride (GRA) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. In this study, iontophoretic permeation of GRA through guinea pig skin...

Grey relational analysis (GRA) is a vital instrument suitable for optimal selection which can be used for modelling, forecasting and decision making. Grey theory gives reliable solution of systems in which the model is poor with little or incomplete information. This paper aims to use GRA for solving Multi Criteria Robot Selection Problems (MCRSPs). In this paper, GRA steps are implemented usin...