Let Δ be an abelian group. By considering the notion multiplication of Δ-graded modules (see [7]) over a commutative Δ-graded ring with unity, we introduce the notion of product of two Δ-graded submodules which we use to characterize the Δ-graded prime submodules of a multiplication Δ-graded module. Finally we proved a graded version of Nakayama lemma for multiplication Δ-graded modules.