BACKGROUND AND OBJECTIVES Rhabdomyolysis is often associated with sepsis and gram positive bacterial pathogens are reported to be the most frequent cause of sepsis induced rhabdomyolysis. We report the pattern of infecting bacterial pathogens and associated causal factors in a South-Indian cohort. DESIGN, SETTING, PARTICIPANTS #ENTITYSTARTX00026; MEASUREMENTS Retrospective cohort study of adu...

Multidrug-resistant Gram-negative induced sepsis poses an increasing threat to the vulnerable intensive care patient. The study by Toufekoula and colleagues reports the serum and tissue concentration of malondialdehyde (MDA), the toxic end product of lipid peroxidation, during the course of experimental and human Gram-negative sepsis. The complementary results from this dual experimental and cl...

Sepsis, characterized by a systemic inflammatory state that is usually related to Gram-negative bacterial infection, is a leading cause of death worldwide. Although the annual incidence of sepsis is still rising, the exact cause of Gram-negative bacteria-associated sepsis is not clear. Outer membrane vesicles (OMVs), constitutively secreted from Gram-negative bacteria, are nano-sized spherical ...

BACKGROUND Neonatal sepsis is one of the major causes of morbidity and mortality among the newborns in the developing world. OBJECTIVES To determine the common bacterial isolates causing sepsis in neonatal intensive care unit and its antibiotic susceptibility pattern. METHODS A one year discriptive prospective study was conducted in neonatal intensive care unit to analyse the results of blo...

background: neonatal septicemia is an important cause of morbidity and mortality. the most common pathogens of bacterial sepsis and antibiotic sensitivity patterns may vary in different areas of the world. understanding the etiology of bacteriological profiles is very important and helps to reduce the associated mortality. the aim of this study was to assess prevalence of bacterial and antibiot...

Sepsis caused by gram-negative bacteria and that caused by gram-positive bacteria often manifest similar clinical features. We investigated plasma proinflammatory cytokine profiles in patients with sepsis due to gram-positive and gram-negative bacteria and studied the cytokine production and differential gene regulation of leukocytes stimulated ex vivo with Escherichia coli lipopolysaccharide o...

Background: Neonatal sepsis is one of the most important causes of infant mortality in developing countries. The causative organisms for sepsis are various in different regions across the world. The aim of this study was to determine the frequency of microbial agents and drug resistance pattern of the neonatal sepsis in newborns admitted to the neonatal intensive care unit (NICU) at Alzahra Hos...