BACKGROUND The objective of this in-vitro study was to evaluate the effect of grape seed extract (oligomericproanthocyanidin complexes [OPCs]) on the bond strength of composite resin to bleached enamel using 5th and 7th generations of bonding agents. MATERIALS & METHODS Eighty maxillary central incisors were randomly assigned to four groups as follows: Group I (n=20): no bleaching (control); ...

Proanthocyanidins, extracted from grape seeds, are widely used mainly as nutritional supplements. However, there has not been a systematic report to investigate toxicological studies on proanthocyanidins, especially in oral administration. In our studies, proanthocyanidin-rich extract from grape seeds was subjected to a series of toxicological tests to document its safety for use in various foo...

BACKGROUND AND PURPOSE Tissue hardness (induration), pain and tenderness are common late adverse effects of curative radiotherapy for early breast cancer. The purpose of this study was to test the efficacy of IH636 grape seed proanthocyanidin extract (GSPE) in patients with tissue induration after high-dose radiotherapy for early breast cancer in a double-blind placebo-controlled randomised pha...

Grape seed extract (GSE) is one of Japan's natural food additives, and is recommended for use as an antioxidant. The component of interest is polyphenol, mainly proanthocyanidins, which are condensed tannins. A vanillin-hydrochloric acid (HCl) assay is specific for flavan-3-ol. The sensitivity of GSE components to the vanillin-HCl assay differed according to the chemical structure. We applied t...

The initial concentration of anthocyanin and proanthocyanidin in wine affects the development SO 2 -resistant pigments, as well color non-color contributing polymeric fractions. However, effect extracted monomeric Pinot Noir ( Vitis vinifera L. cv.) grape anthocyanins with seed proanthocyanidins are poorly studied. In model ferments, reaction purified cv. noir extract were investigated at high ...

Apoptosis of lymphocytes is associated with immunosuppression and poor prognosis in sepsis. Our previous report showed that histones, nuclear proteins released from damaged or dying cells in sepsis, can mediate lymphocyte apoptosis via mitochondria damage. Grape seed proanthocyanidin extract (GSPE), a natural substance with protective properties against oxidative stress, plays a vital role in c...

To evaluate the utility of fruits and by-products/wastes as bioactive materials, we investigated anti-allergic effects hot-water ethanol extracts from various fruit by-products medicinal using a β-hexosaminidase release assay. Bile acid-binding ability, which is related to acceleration bile acid excretion, was also determined for extracts. Among extracts, extract grape bunch stem showed highest...