نتایج جستجو برای: growth plate
تعداد نتایج: 884936 فیلتر نتایج به سال:
Loss of epidermal growth factor receptor (EGFR) activity in mice alters growth plate development, impairs endochondral ossification, and retards growth. However, the detailed mechanism by which EGFR regulates endochondral bone formation is unknown. Here, we show that administration of an EGFR-specific small-molecule inhibitor, gefitinib, into 1-month-old rats for 7 days produced profound defect...
The epiphyseal growth plate is a developmental region responsible for linear bone growth, in which chondrocytes undertake a tightly regulated series of biological processes. Concomitant with the cessation of growth and sexual maturation, the human growth plate undergoes progressive narrowing, and ultimately disappears. Despite the crucial role of this growth plate fusion "bridging" event, the p...
We have tested the hypothesis that maturation-dependent changes in the cortical plate affect the spatiotemporal growth patterns of developing thalamocortical and corticocortical axonal projections. Given a choice between alternating lanes of embryonic (E18-19) and neonatal (P0-1) rat cortical plate membranes, embryonic (E18-19) thalamic and cortical neurites prefer to extend on neonatal membran...
Tissue-engineered technology has provided a promising method for the repair of growth plate injuries using biocompatible and biodegradable scaffolds and appropriate cells. The aim of this study was to fabricate oriented ECM scaffolds to imitate the material and structure of a natural growth plate and to investigate whether BMSCs in a scaffold could prevent the formation of bone bridges in an in...
B Dietary Vitamin D Deficiency Disrupts the Spatial Pattern of Growth Plate Mechanical Properties +Sevenler, D; Buckley, M; Kim, G; van der Meulen, MCH; Cohen, I; Bonassar, L; +Mechanical & Aerospace Engineering, Physics, Biomedical Engineering, Cornell University, Ithaca NY [email protected] INTRODUCTION Rickets is a debilitating disease caused by deficient mineralization at the growth plate d...
BACKGROUND Children need physical activity and generally do this through the aspect of play. Active play in the form of organized sports can appear to be a concern for parents. Clinicians should have a general physiological background on the effects of exercise on developing epiphyseal growth plates of bone. The purpose of this review is to present an overview of the effects of physical activit...
Spondylolysis is a stress fracture of the pars interarticularis, which in some cases progresses to spondylolisthesis (forward slippage of the vertebral body). This slip progression is prevalent in children and occurs very rarely after spinal maturation. The pathomechanism and predilection for children remains controversial despite considerable clinical and basic research into the disorder over ...
Introduction: The progression of spondylolysis (lysis) to spondylolisthesis (olisthesis) is more prevalent among children and occurs most often in the adolescent growth spurt. End-plate lesions, lumbar lordosis, and disc degeneration have been implicated as being possible risk factors. How these factors influence the pathomechanism of the disorder is not clearly understood and the most critical...
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