Rat liver glutamine transaminase acts on y-glutamyl hydrazones of a-keto acids to yield the corresponding L-amino acids and 3-hydroxy-tetrahydro-6-pyridazinone-3-carboxyllc acid; the latter compound undergoes nonenzymatic dehydration in acid to yield 1,4,5,6-tetrahydro-6-pyridazinone -3carboxylic acid. L-Amino acid oxidase (snake venom) also catalyzes the formation of 3-hydroxy-tetrahydro-6-pyr...

The recently characterized corticosteroid receptor on amphibian neuronal membranes appears to mediate rapid, stress-induced changes in male reproductive behaviors. Because the transduction mechanisms associated with this receptor are unknown, we performed radioligand binding studies to determine whether this steroid receptor is negatively modulated by guanyl nucleotides. The binding of [3H]cort...

An enantioselective hydrogenation of fluorinated hydrazones has been achieved by employing [Pd(R)-DTBM-SegPhos(OCOCF3)2] as the catalyst, providing a general and convenient method toward chiral fluorinated hydrazines. A broad substrate scope including β-aryl-, γ-aryl-, and alkyl-chain-substituted hydrazones worked efficiently in high yields and up to 94% of enantioselectivity. The reductive ami...

Ascorbate Determination, 2,4-Dinitrophenylhydrazine Microamounts of vitamin C could be readily determined in 20 ul-samples using the 2,4-dinitrophenylhydrazine method together with separation by thin layer chromato­ graphy. The condensation reaction was carried out for 5 min at 100 °C on a glass fibre disc. Purification of vitamin C hydrazones was accomplished by repeated separation on TLC plat...

α,β-Unsaturated N,N-dialkyl hydrazones undergo a mild [2 + 2] cycloaddition to allenamides when treated with a suitable gold catalyst. The method, which represents the first application of N,N-dialkyl hydrazones in gold catalysis, is compatible with a wide variety of substituents at the alkenyl moiety of the hydrazone component, proceeds with excellent levels of regio- and diastereoselectivity,...

Hydrazones and their derivatives constitute a versatile class of compounds in organic chemistry. The development of novel hydrazones containing compounds possess a wide verities of biological activities like as antioxidant, anti-inflammatory, anticonvulsants, antidepressant and anxiolytic, antihypertensive, anticancer, antimicrobial, anti-tuberculosis, and antifungal activity. Hydrazones posses...

Dr. Juan Tamayo was the recipient of a fellowship from Consejo Nacional de Ciencia y Tecnologia, Mexico (CONACYT). Dr. Ezequiel Bellorin-Font was the recipient of a fellowship from Consejo Nacional Investigationes Cientificas y Tecnologicas, Venezuela (CONICIT). Received for publication 23 June 1982 and in revised form 5 April 1983. by guanyl nucleotides in vitro, and the effects of guanyl nucl...

OF THE THESIS Synthesis, Characterization and Biological Activities Of Novel Hybrid Molecules Related to Substituted Hydrazones, Sulphonamides and Sulphonates of NonSteroidal Anti-Inflammatory Drugs CHAPTER 1 A Brief Overview of Synthesis and Pharmacological Activities of Substituted Hydrazones, Sulphonates and Sulphonamides This chapter deals with general survey of the literature related to th...

Hydrazines and their derivatives are versatile artificial and natural compounds that are metabolized by elusive biological systems. Here we identified microorganisms that assimilate hydrazones and isolated the yeast, Candida palmioleophila MK883. When cultured with adipic acid bis(ethylidene hydrazide) as the sole source of carbon, C. palmioleophila MK883 degraded hydrazones and accumulated adi...