BACKGROUND In previous studies, the relaxant, anticholinergic (functional antagonism) and antihistaminic effects of Nigella sativa have been demonstrated on guinea pig tracheal chains. To elucidate the other mechanisms responsible for the relaxant effect of this plant, its inhibitory effect on the calcium channel was examined in this study. RESULTS The inhibitory effects of both concentration...

Two types of light polypeptide chain (kappa and lambda) are present in guinea pig immunoglobulins. The ratios of K/L molecules in anti-hapten antibodies differ sometimes markedly from that found in normal serum. Anti-DNP antibodies and anti-pipsyl antibodies have, respectively, a higher and a lower than normal K/L ratio. The possibility that the L chain type affects the range of configurations ...

Objective(s) In the present study, the differences in the relaxant effects of aqueous, ethyl acetate and n-butanol fractions of Rosa damascena on tracheal smooth muscle of guinea pigs were examined. Materials and Methods The relaxant effects of three cumulative concentrations of each fraction (0.1, 0.2 and 0.4 g%) in comparison with saline and three cumulative concentrations of theophylline ...

conclusions these results showed the preventive effect of hydroethanolic extract of n. sativa on tracheal responsiveness of guinea pig model of copd, which was as effective as vitamin c. results the tracheal responsiveness to both methacholine and ovalbumin in guinea pigs with copd were significantly higher than those of controls (p < 0.001 for both cases). the tracheal responsiveness in the co...

Our previous studies have demonstrated the relaxant, anticholinergic (functional antagonism), antihistaminic, and inhibitory effect of calcium channels of Nigella sativa on guinea pig tracheal chains. To investigate the other mechanism responsible for the relaxant effect of this plant, the stimulatory effect of Nigella sativa on ß 2 -adrenergic receptors in tracheal chains of the guinea pig was...

objective in previous studies, the relaxant, anticholinergic (functional antagonism), antihistaminic and its stimulatory effects on b-adrenoceptors of nigella sativa have been demonstrated on guinea pig tracheal chains. in the present study, the relaxant effects of hydro-ethanolic, macerated aqueous (ma) and lipid-free macerated aqueous (lfma) extract of nigella sativa on tracheal chains of gui...

BACKGROUND In previous studies, the bronchodilator and antitussive effects of Nigella sativa have been demonstrated on guinea pigs. OBJECTIVES In the present study, the effect of the hydroethanolic extract of N. sativa on tracheal responsiveness in guinea pigs exposed to cigarette smoke was examined. MATERIALS AND METHODS Three groups of guinea pig models of COPD were given drinking water a...

Objective: The use of drugs with herbal origin is increasing for treatment of gastrointestinal (GI) disorders. Rosa damascena (R. damascena) is a well-known plant suggested to have beneficial effect on GI system. In this study, the effect of aqueous fraction of R. damascena on the contractionsofisolated guinea pig ileum was investigated. Materials and Methods: Aqueous fraction of plant was obta...

Hexane extract of the seeds of Nigella sativa L. prevented pregnancy in Sprague-Dawley rats treated orally at 2 g/kg daily dose on days 1-10 post-coitum. Significant antifertility activity was also observed in its column fractions and subfractions. At contraceptive dose, the active hexane extract exhibited only mild uterotrophic activity comparable almost to 0.002 mg/kg dose of 17 varies; is di...

Xanthine oxidase activity containing fractions from rat, mouse, rabbit and guinea pig livers were obtained by heat treatment and ammonium sulfate precipitation. Xanthine oxidase activity was observed in rat and mouse liver fractions, while xanthine oxidase activity was absent in rabbit and guinea pig liver fractions. Enzyme kinetic parameters, K m and V max , were determined for the conversion ...