Let h1, · · · , hn be positive integers. We study new sums m(h1, · · · , hn) = h1−1 ∑ r1=0 · · · hn−1 ∑ rn=0 min { r1 h1 , · · · , rn hn } and M(h1, · · · , hn) = h1−1 ∑ r1=0 · · · hn−1 ∑ rn=0 max { r1 h1 , · · · , rn hn } , the first of which times h1 · · ·hn is the number of lattice points in a pyramid of dimension n + 1. We show that m(h1, · · · , hn) (h1 − 1) · · · (hn − 1) = 1 + ∑ ∅6 =I⊆{1...

The methylated DNA binding protein-2-H1 (MDBP-2-H1), present in rooster liver, is a member of the histone H1 family which inhibits transcription by binding selectively to methylated promoters. Here we have determined the primary structure of MDBP-2-H1. A comparison between histone H1 and MDBP-2-H1 was achieved by analyzing reversed phase HPLC-purified and V8-digested proteins by mass spectromet...

In this report, we investigate the mechanisms that regulate Drosophila histone H1 expression and its association with chromatin in vivo. We show that histone H1 is subject to negative autoregulation and exploit this result to examine the effects of mutations of the main phosphorylation site of histone H1.

Multiple non-allelic subtypes of histone H1 have been detected in higher organisms. These specific variants with distinct structural features may differ in their ability to condense chromatin and hence modify transcriptional activity. Such functional divergence between H1 subtypes has still not been established definitively, but it cannot be excluded that the role of a particular subtype may de...

Nm23 genes, which encode nucleoside diphosphate kinases, have been implicated in suppressing tumor metastasis. The motility of human breast carcinoma cells can be suppressed by transfection with wild-type nm23-H1, but not by transfections with two nm23-H1 mutants, nm23-H1(S12OG) and nm23-H1(P96S). Here we report that nm23-H1 can transfer a phosphate from its catalytic histidine to aspartate or ...

.................................................................................................. 10 POPULÄRVETENSKAPLIG SAMMANFATTNING............................. 12 PAPERS IN THE PRESENT THESIS ....................................................... 15 ABBREVIATIONS ....................................................................................... 16 INTRODUCTION..........................