نتایج جستجو برای: haematopoiesis
تعداد نتایج: 658 فیلتر نتایج به سال:
The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of PU.1 has proved challenging. This paper will discuss how a range of experiments in cell lines and mutant and transgenic mouse models have enhanced...
Specific deletion of Notch1 and RBPjkappa in the mouse results in abrogation of definitive haematopoiesis concomitant with the loss of arterial identity at embryonic stage. As prior arterial determination is likely to be required for the generation of embryonic haematopoiesis, it is difficult to establish the specific haematopoietic role of Notch in these mutants. By analysing different Notch-l...
Transcription factors (TFs) act withinwider regulatory networks to control cell identity and fate. Numerous TFs, including Scl (Tal1) and PU.1 (Spi1), are known regulators of developmental and adult haematopoiesis, but how they act within wider TF networks is still poorly understood. Transcription activator-like effectors (TALEs) are a novelclassofgenetic toolbasedon themodularDNA-bindingdomain...
A 50-year-old man with a 20-year history of myelofibrosis developed mild impairment of dorsal column sensation and ataxia of gait. A myelogram and subsequent peroperative biopsy demonstrated spinal cord compression due to extramedullary haematopoiesis. There was an excellent clinical response to surgery and radiotherapy. The characteristic clinical features and the pathogenesis of this unusual ...
In this work, we introduce a similarity-network-based approach to explore the role of interacting single-cell histone modification signals in haematopoiesis—the process differentiation blood cells. Histones are proteins that provide structural support chromosomes. They subject chemical modifications—acetylation or methylation—that affect degree accessibility genes and, turn, formation different...
This study was made to determine the nature of tissue contributions to murine hepatic morphogenesis, the developmental potential in vitro of various hepatic regions prior to and during definitive liver development, and to accurately determine the time of onset of hepatic haematopoiesis in vitro. Embryos were precisely staged by somite counts as well as time of original mating, and tissues were ...
To the editor: In recent decades it has been shown that parathyroid hormone could influence haematopoiesis through a direct action on haematopoietic precursors: at low concentration, parathormone could stimulate haematopoiesis and, in contrast, would be inhibitory at high concentration. Furthermore, about 10 cases of polycythaemia associated with hyperparathyroidism have been reported (1-8). We...
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