Hair follicle stem cells in the hair follicle bulge area of mice are nestinand CD34-positive, and keratin 15 (K15)negative. The mouse hair follicle stem cells are multipotent and can differentiate into neurons, glial cells, keratinocytes, smooth muscle cells, and melanocytes (Proc. Natl. Acad. Sci. USA 102, 5530-5534, 2005). Recently, pluripotent stem cells have been identified in human hair fo...

INTRODUCTION Recent work has focused on the hair follicle as the main repository of multipotent stem cells in skin, which is a neat model to study the mechanisms regulating the proliferation, migration and final fate of adult stem cells. This review examines the available literature for its location, molecular markers and multipotency. METHODS Peer-reviewed journals and monographs on the subj...

The hair follicle bulge area is an abundant, easily accessible source of actively growing, pluripotent adult stem cells. Nestin, a protein marker for neural stem cells, is also expressed in follicle stem cells as well as their immediate differentiated progeny. The nestin-expressing hair follicle stem cells differentiated into neurons, glial cells, keratinocytes and smooth muscle cells in vitro....

Hair follicle stem cells sustain growth and cycling of the hair follicle and are located in the permanent portion of the follicle known as the bulge. In this issue of the JCI, Ohyama et al. report the characterization of global gene expression patterns of human hair follicle stem cells after their isolation using sophisticated laser capture techniques to microdissect out bulge cells. They disco...

background: the seladin-1 (selective alzheimer disease indicator-1), also known as dhcr24, is a gene found to be down-regulated in brain region affected by alzheimer disease (ad). whereas, hair follicle stem cells (hfsc), which are affected in with neurogenic potential, it might to hypothesize that this multipotent cell compartment is the predominant source of seladin-1. our aim was to evaluate...

Integrin-linked kinase (ILK) is key for normal epidermal morphogenesis, but little is known about its role in hair follicle stem cells and epidermal regeneration. Hair follicle stem cells are important contributors to newly formed epidermis following injury. We inactivated the Ilk gene in the keratin 15--expressing stem cell population of the mouse hair follicle bulge. Loss of ILK expression in...

The regulation of the periodic regeneration of hair follicles is complicated. Although Wnt10b has been reported to induce hair follicle regeneration, the characteristics of induced hair follicles, especially the target cells of Wnt10b, have not yet been clearly elucidated. Thus, we systematically evaluated the expression and proliferation patterns of Wnt10b-induced hair follicles. We found that...

The hair follicle bulge area is an abundant, easily accessible source of actively growing, pluripotent adult stem cells. Nestin, a protein marker for neural stem cells, also is expressed in follicle stem cells and their immediate, differentiated progeny. The fluorescent protein GFP, whose expression is driven by the nestin regulatory element in transgenic mice, served to mark the follicle cell ...

The present investigation explored the in vitro culture, isolation and characterization of hair follicle cell differentiation from umbilical cord blood mesenchymal stem cells (MSCs). Flow cytometry was used to obtain MSCs from the isolation and purification of human umbilical cord blood MSCs. Culture suspension of hair follicle organ was centrifuged and the supernatant used in the culture mediu...