نتایج جستجو برای: hair follicle structures
تعداد نتایج: 504006 فیلتر نتایج به سال:
The formation of epithelial tubes underlies the development of diverse organs. In the skin, hair follicles resemble tube-like structures with lumens that are generated through poorly understood cellular rearrangements. Here, we show that creation of the hair follicle lumen is mediated by early outward movement of keratinocytes from within the cores of developing hair buds. These migratory kerat...
Formations of feather and hair follicles during embryonic stage are nearly similar. The aim of the present research is to study the similarities and differences between these two follicles in adult pigeons and rats. To fulfill this task, feather and hair follicles were dissected and processed for light and electron microscopy. The results demonstrated that these two follicles were similar in ha...
Besides forming hair shafts, the highly organized, metabolically vigorous hair follicle plays several crucial roles in skin architecture. The follicle contains a distinct population of presumptive follicular stem cells that express nestin, also a marker for neural stem cells. These nestin-expressing follicle cells are located principally in the follicular bulge region. Nestin-driven GFP (ND-GFP...
Emergence and spread of various diseases in the past century have been associated with many problems for the health care providers. Now a days, with advancement of technology, new methods such as cell therapy, are available, efficient and successful in some clinical areas. To use any cell, it is necessary to identify its source, so herein, we reviewed the literature of a new source of adult ste...
Despite the significant advances in regenerative medicine, wound healing has remained a challenging clinical problem. Skin is the largest human organ with many vital functions; therefore, any damage to its normal structure should be treated as soon as possible. Easy access to skin stem cells has created a lot of excitement in therapeutic applications. “Cell therapy” is considered a novel method...
There are many cell types in the hair follicle, including hair matrix cells which form the hair shaft and stem cells which can initiate the hair shaft during early anagen, the growth phase of the hair cycle, as well as pluripotent stem cells that play a role in hair follicle growth but have the potential to differentiate to non-follicle cells such as neurons. These properties of the hair follic...
Hair is maintained through a cyclic process that includes periodic regeneration of hair follicles in a stem cell-dependent manner. Little is known, however, about the cellular and molecular mechanisms that regulate the layered differentiation of the hair follicle. We have established a mutant mouse with a cyclic alopecia phenotype resulting from the targeted disruption of Sox21, a gene that enc...
Wnt proteins are secreted molecules that play multiple roles during hair follicle development and postnatal hair cycling. Wntless (Wls) is a cargo protein required for the secretion of various Wnt ligands. However, its role during hair follicle development and hair cycling remains unclear. Here, we examined the expression of Wls during hair follicle induction and postnatal hair cycling. We also...
According to the growth state of hair follicles, the hair cycle is divided into the anagen, catagen and telogen phases. A number of biological factors have been shown to synchronize with the hair cycle. As an important component of the hair follicle, the extracellular matrix is regulated by matrix metalloproteinases (MMPs) and their inhibitors (tissue inhibitor of matrix metalloproteinases; TIM...
Background: One of the key questions in biochemistry is why cell becomes aged and what are the involved factors? Why cell growth is stopped after some divisions and cells become senescent? This occurs in a greater frame in the whole body and cells dye after a while. Androgenetic alopecia (AGA) is characterized by a loss or decrease in hair follicle size, which could be related to the loss of ha...
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