BACKGROUND There is evidence that glycosaminoglycans (GAGs) are present in the hair shaft within the follicle but there are no studies regarding GAGs isolation and measurement in the human hair shaft over the scalp surface, it means, in the free hair shaft. OBJECTIVE The purpose of our research was to isolate and measure the total GAGs from human free hair shaft. METHODS Seventy-five health...

Exposing wet hair to high temperatures can create gas bubbles within the hair shaft, leading to brittle, dry hairs in a disorder known as bubble hair abnormality. We present a case of a 61-year-old woman who presented for hair breakage over her crown. She regularly dried her damp hair with a blow dryer. Dermoscopy revealed multiple bubbles within the hair shaft, and diagnosis of bubble hair abn...

Mutant laboratory mice with distinctive hair phenotypes are useful for identifying genes responsible for hair diseases. The work presented here demonstrates that shotgun proteomic profiling can distinguish hair shafts from different inbred mouse strains. For this purpose, analyzing the total hair shaft provided better discrimination than analyzing the isolated solubilized and particulate (cross...

L. Rudnicka et al. (eds.), Atlas of Trichoscopy, DOI 10.1007/978-1-4471-4486-1_2, © Springer-Verlag London 2012 Most hairs viewed on trichoscopy are normal terminal hairs that are more than 55 m m wide and are uniform in thickness and color [ 1, 2 ] . Hair shaft thickness may be roughly estimated with a handheld dermoscope (thin, normal, thick). Many videodermoscopes include software allowing a...

The hair of all mammals consists of terminally differentiated cells that undergo a specialized form of apoptosis called cornification. While DNA is destroyed during cornification, the extent to which RNA is lost is unknown. Here we find that multiple types of RNA are incompletely degraded after hair shaft formation in both mouse and human. Notably, mRNAs and short regulatory microRNAs (miRNAs) ...

The hair shaft is a unique structure composed of an inner cortex and a protective outer cuticle. Any defects in this normal structure due to genetics or the environment can lead to variations in physical properties. Thus one should suspect a hair shaft disorder if a patient presents with an abnormality or change in hair texture, appearance, manageability or ability to grow hair long. A key feat...

a 3.5 month-old girl was admitted with silvery gray hair, light  colored skin, recurrent diarrhea, chest infections, hepatosplenomegaly, episodes of pancytopenia, and hemophagocytosis in the bone marrow. light microscopy of hair showed characteristic large and irregular clumps of melanin in the middle of hair shaft. peripheral blood smear examination did not show giant granules in granulocytes....

Uncombable hair syndrome (UHS) is a rare structural anomaly of the hair shaft, which is characterized by dry, frizzy, tangled and rough hair (1). It is usually isolated finding without associated abnormalities. Although most disorders of hair shaft can be diagnosed by light microscopy, UHS requires scanning electron microscopy (SEM) evidence for diagnosis (2). A few recent reports suggest the u...

On scalp hair examination, there were multiple white‐to‐brownish, firm‐to‐hard, 2–3 mm sized nodules distributed at irregular interval and encircling the hair shaft completely [Figure 1]. The nodules could not be slid over the hair shaft. Moreover, structures resembling nits were seen in the retroauricular area. Hair pull test and tug test were negative. Scalp was otherwise normal with no signs...

There are many cell types in the hair follicle, including hair matrix cells which form the hair shaft and stem cells which can initiate the hair shaft during early anagen, the growth phase of the hair cycle, as well as pluripotent stem cells that play a role in hair follicle growth but have the potential to differentiate to non-follicle cells such as neurons. These properties of the hair follic...