Objetives: Recovery of upper limb motor function in stroke is limited. Different approaches are used to improve the upper limb function, but none has satisfactory results. The present study investigated the effect of task related training and role of hand dominance in upper limb motor function rehabilitation in stroke population. Methods: A convenient sample of 32 subjects divided into 4 gro...

objective(s):neurotoxicity of anticancer drugs complicates treatment of cancer patients. vinblastine (vbl) is reported to induce motor and cognitive impairments in patients receiving chronic low-dose regimen. materials and methods: the effects of vbl treatment on motor, learning and memory functions of male and female wistar rats were studied by behavioral related tests. animals were given chro...

PURPOSE The complexity of upper extremity (UE) behavior requires recovery of near normal neuromuscular function to minimize residual disability following a stroke. This requirement places a premium on spontaneous recovery and neuroplastic adaptation to rehabilitation by the lesioned hemisphere. Motor skill learning is frequently cited as a requirement for neuroplasticity. Studies examining the ...

BACKGROUND AND PURPOSE Reorganization of brain function may result in preservation of motor function in patients with brain tumors. The goal of the present study was to investigate whether function of the primary motor area (M1) was restored and whether motor function improved after brain tumor resection. METHODS Five patients with metastatic brain tumors located within or near M1 underwent a...

Transcranial direct current stimulation (tDCS) is a non-invasive powerful method to modulate brain activity. It can enhance motor learning and working memory in healthy subjects. To investigate the effects of anodal tDCS (1 mA, 20 min) of the dominant and non-dominant primary motor cortex (M1) on hand motor performance in healthy right-handed volunteers, healthy subjects underwent one session o...

OBJECTIVE To investigate the association between damage to different levels of the corticofugal tract and long-term hand motor recovery. DESIGN Prospective cohort study. PATIENTS Seventy-five first-ever middle cerebral artery stroke survivors. METHODS Hand motor function was assessed with the Fugl-Meyer Motor Assessment Scale at one year post-stroke. Localization of the corticofugal tract...

OBJECTIVE Rett syndrome is a rare neurodevelopmental disorder that is usually associated with a mutation on the X-linked MECP2 gene. Hand function is particularly affected and we discuss theoretical and practical perspectives for optimising hand function in Rett syndrome. METHODS We reviewed the literature pertaining to hand function and stereotypies in Rett syndrome and developed a toolkit f...

OBJECTIVE To evaluate motor excitability and hand function on the non-dominant side according to the polarity of transcranial direct current stimulation (tDCS) on the motor cortex in a healthy person. METHOD tDCS was applied to the hand motor cortex for 15 minutes at an intensity of 1 mA in 28 healthy right-handed adults. Subjects were divided randomly into four groups: an anodal tDCS of the ...