ISIS är ett centrum med nio industripartners och sex forskningsgrupper, med inriktning mot industriella styroch övervakningsproblem, och med syfte att använda och utveckla verktyg b̊ade fr̊an datavetenskap och reglerteknik. De största utmaningarna för ett kompetenscentrum är att h̊alla en bra balans mellan vetenskaplig production och industriellt relevans, att producera välutbildade personer och a...

Harmaline (HAR), a natural occurrence β-carboline alkaloid, was isolated from the seeds of Peganum harmala and exhibited potent antitumor effect. In this study, the anti-gastric tumor effects of HAR were firstly investigated in vitro and in vivo. The results strongly showed that HAR could inhibit tumor cell proliferation and induce G2/M cell cycle arrest accompanied by an increase in apoptotic ...

Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone receptor superfamily. In this work, the effect of androgens and antiandrogens on the expression of the human androgen receptor (hAR) in prostate and breast cancer cell lines was studied. Northern blot analysis revealed a decrease in hAR steady state RNA levels in LNCaP cells by 3.3 nM of the syntheti...

Gobind Khorana was a scientist who traversed boundaries, both scientifically and culturally. He pioneered the use of concepts and tools from chemistry and physics to tackle fundamental questions of biology. In particular, he helped to decipher how RNA encodes for the synthesis of protein, research that earned him the Nobel Prize in Medicine with Marshall Nirenberg and Robert Holley in 1968. Alt...

Aldose reductase (AR), an enzyme mediating the first step in the polyol pathway of glucose metabolism, is associated with complications of diabetes mellitus and increased cardiac ischemic injury. We investigated whether deleterious effects of AR are due to its actions specifically in cardiomyocytes. We created mice with cardiac specific expression of human AR (hAR) using the α-myosin heavy chai...

OBJECTIVE Mouse models possessing green fluorescent protein (GFP) and/or human aldose reductase (hAR) in vascular tissues have been established and crossed with naturally diabetic Akita mice to produce new diabetic mouse models. RESEARCH DESIGN AND METHODS Colonies of transgenic C57BL mice expressing GFP (SMAA-GFP), hAR (SMAA-hAR) or both (SMAA-GFP-hAR) in vascular tissues expressing smooth m...

Measuring and comparing performance, cost, and other attributes of SpaceWire networks is a significant challenge. A new benchmark for SpaceWire-based satellites is presented. The benchmark contains a potential architecture of a multi-mission satellite, as well as specifications of the traffic flow. The proposed benchmark is demonstrated on an OPNET-based network simulation for various network c...

Retranslocation of N, P, K, Ca, Mg, Mn, Fe, Zn, Cu and Ni within the foliage of Scots pine (Pinus sylvestris L.) was studied during autumnal needle senescence along a heavy-metal pollution gradient in western Finland. The stands were located at distances of 0.5 (Har 0.5), 4 (Har 4) and 8 km (Har 8) to the southeast of a copper-nickel smelter at Harjavalta. A background study stand was located a...

År 2004 har varit det första året av Fas IV. Under året har fördjupningen och utvidgningen av samarbetet fortsatt mellan de deltagande företagen och forskargrupperna vid LiTH (Linköpings Tekniska Högskola) och har resulterat i industriellt relevanta forskningsresultat. Huvudaktiviteten inom ISIS är forskningsprojekten. Projekten har valts ut för att vara av central betydelse för företagen. Att ...

Handheld augmented reality (HAR) is an expanding novel technology and user studies are very important part for driving its design activities. In order to form design guidelines and principles, it is important to gain better understanding of the usage of HAR systems. This paper describes the iterative design process of a state-of-the-art pragmatic simultaneous localization and mapping (SLAM) bas...