METHODS: Thirty-six male Sprague–Dawley rats aged 7 weeks were divided into two groups. The Achilles tendon was transected and repaired with modified Kessler’s method. In the experimental group (n = 18), the rats received daily intraperitoneal administration of PDRN (8mg/kg/day for 1, 2, 4 weeks). The control groups received same amount intraperitoneal injections of the normal saline. The rats ...

Humans have been harvesting wild populations for the entire extent of human history. In most early human societies, a successful hunt not only fed one’s family, but also brought respect from both family and community (Bolen and Robinson 2002). Although most North Americas and western Europeans today acquire their food that was planted, harvested, and processed by someone else, hunting and harve...

Vascular relaxation in rabbit aortic preparations induced by acetylcholine is endothelium-dependent. The nature of the endothelium-derived relaxing factor (EDRF) has not been ascertained because it is very labile (reported half-life 6-50 seconds). To obtain a stable source of EDRF, a system was developed in which the relaxing factor was continuously produced by freshly harvested porcine endothe...

Evidence is presented that a tumor-derived transforming growth factor is responsible for stimulating bone resorption and causing hypercalcemia in an animal tumor model of the hypercalcemia of malignancy. Both conditioned medium harvested from cultured tumor cells and tumor extracts of the transplantable rat Leydig cell tumor associated with hypercalcemia contained a macromolecular bone resorbin...

The ascorbate content declined rapidly in broccoli (Brassica oleracea L. var. italica) florets, but not in the stem tissue, during post-harvest senescence. Ascorbate peroxidase (APX), ascorbate oxidase (AO), l-galactono-1,4-lactone dehydrogenase (GLDH), monodehydroascorbate reductase (MDAR), dehydroascorbate reductase (DHAR), and glutathione reductase (GR) were investigated in gene expression a...

OBJECTIVE Knowledge regarding prognostic factors in gastric cancer is essential to decide on single patient management. We aim to establish the value of large lymph node size in order to improve perioperative approach. MATERIAL AND METHODS Charts of one hundred and twenty-eight consecutive patients undergoing gastrectomy for resectable gastric cancer were reviewed between January 1996 and Dec...

The effects of cell contacts and the attachment of cells to the substratum on growth-factor-induced survival of 3T3-L1 cells were investigated to clarify their involvement in the maintenance of cell viability. When 3T3-L1 cells in low-density cultures or in high-density cultures were harvested with EDTA solution and cultured in the absence of calf serum, almost all cells from the low-density cu...