نتایج جستجو برای: hat1
تعداد نتایج: 133 فیلتر نتایج به سال:
Esophageal carcinoma (EC) is one of the most fatal carcinomas of the gastrointestinal tract. Aberrant activity of histone acetyltransferases (HATs)/deacetylases (HDACs) play a critical role in carcinogenesis through the regulation of the genes involved in cell differentiation, proliferation, and apoptosis. However, cellular functions of HATs/HDACs in esophageal cancer and its molecular mechanis...
Histopathology is a critical approach for diagnostic tasks and precision treatment. However, histopathological deep learning tools auto-identification remain poorly developed. Meanwhile, the interpretation of computer vision attention into cellular process less efficient in systematic way. Herein, it identified that histone acetyltransferase 1 (HAT1) an aging-associated gene esophagus epitheliu...
Hot and dry air (harmattan or xerothermic climate) greatly inhibits plant growth, particularly Xowering and seed setting of crops. Little is known about the mechanism of plant response to this extreme environmental stress due to the lack of valuable genetic resource. Here, we report the isolation and characteristics of a unique Arabidopsis mutant, hat1 (harmattan tolerant 1), which shows high t...
Trichome initiation and leaf growth are two critical developmental processes in the plant life cycle, which need to be optimized accordance with stage immediate surroundings. To a large extent, this optimization is achieved by fine-tuning of hormonal pathways, including gibberellin (GA) pathway. However, mechanism plants control GA homeostasis optimize these unknown. Here, we report that HAT1, ...
Histone acetyltransferases (HATs) are separated into two types. Type A HATs act on nucleosomal histones and thus primarily function in transcriptional regulation, while cytoplasmic (type B) known as enzymes that modify free before their assembly chromatin, may also outside the nucleus. N-alpha-acetyltransferase 60 (NAA60) is most recently discovered type B HATs, which N-terminal (NATs) found on...
It is generally accepted that the surfactant-producing pulmonary alveolar epithelial type II (AT2) cell acts as the progenitor of the type I (AT1) cell, but the regulatory mechanisms involved in this relationship remain the subject of active investigation. While previous studies have established a number of specific markers that are expressed during transdifferentiation from AT2 to AT1 cells, w...
Condensin is a central regulator of mitotic genome structure with mutants showing poorly condensed chromosomes and profound segregation defects. Here, we identify NCT, a complex comprising the Nrc1 BET-family tandem bromodomain protein (SPAC631.02), casein kinase II (CKII), and several TAFs, as a regulator of condensin function. We show that NCT and condensin bind similar genomic regions but on...
Human fungal pathogens like Candida albicans respond to host immune surveillance by rapidly adapting their transcriptional programs. Chromatin assembly factors are involved in the regulation of stress genes by modulating the histone density at these loci. Here, we report a novel role for the chromatin assembly-associated histone acetyltransferase complex NuB4 in regulating oxidative stress resi...
The role of striatin interacting protein 2 (Strip2) in differentiation of embryonic stem cells (ESCs) is still under debate. Strip2-silenced murine (KD) ESCs were differentiated for 4, 8, 12, and 16 days. We show that Strip2 is distributed in the perinucleus or nuclei of wild-type (WT) undifferentiated ESCs, but is localized in high-density nuclear bodies in differentiated cells. CellNet analys...
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