introduction: hepatocellular carcinoma (hcc) is sixth common cancers worldwide and predominant in asia and africa. a number of evidence suggests a possible role of midkine (mdk) and α-fetoprotein (afp) in the pathogenesis of hepatocellular carcinoma (hcc). materials and methods: we studied mdk and afp in patients with hcc or in healthy controls. mdk and afp was measured by enzyme linked immunos...

Background: Hepatocellular carcinoma (HCC) is common all over the world as well as Iran. The incidence of HCC is higher in hepatitis B carriers and it is highly recommended to periodically screen these patients by serum alpha-fetoprotein (AFP) and liver ultrasound (US) every 6 months. We explore the diagnostic accuracy and the performance of (AFP) in cases of hepatitis B carriers as a scree...

Common techniques for the treatment of Hepatocellular carcinoma (HCC) have not been successful, and thus the design and discovery of new compounds with better anti-cancer function are needed. Snake venom is among the most important compounds used by researchers to the treatment of various cancers. This study was designed to evaluate the toxicity effect of Persian Gulf snake venom (Enhydrina sch...

hepatocellular carcinoma (hcc) represents one of the most common neoplasms worldwide.  liver trasnplantation (lt) is the treatment of choice for selected group of patients with hcc. lt is actually a consolidated therapeutic option for hcc because it cures both tumor and underlying cirrhosis. in 1996, the publication of a pivotal prospective study on less than 50 patients, transplanted for hcc u...

conclusions our results revealed the possible crucial genes and mirnas involved in the initiation and progression of hcc cells infected with hcv. results based on the topological analysis of mirna-hubgene network, we identified the key hub mirnas. in order to identify the most important common sub-network, we aligned two ppi networks using netal tool. the c-jun gene was identified as the most i...

hepatocellular carcinoma (hcc) is the fifth most common tumor in the world, and its incidence is increasing. it is second most common cause of cancer related death worldwide and fastest growing cause of cancer death in the united states. cirrhosis is the most important clinical risk factor for hcc, with approximately 80% of cases of hcc developing in patients with a cirrhotic liver. hcc differs...

background hepatocellular carcinoma (hcc), a major fatal cancer worldwide, is induced by different etiological factors in the liver. objectives to gain insight into serum protein profiling of hcc with different etiologies. patients and methods we subjected the sera of hbv-hcc, hcv-hcc, non-b non-c-hcc patients, and healthy volunteers to two-dimensional gel electrophoresis (2-de) and liquid chro...

Objective(s): MicroRNAs (miRNAs) are considered as powerful, post-transcriptional regulators of gene expression in hepatocellular carcinoma cells (HCC). However, the function of miR-92a is still unclear in HCC. Materials and Methods: Expression of miR-92a in human HCC cell lines was evaluated using qRT-PCR. MTT assay and transwell assay were used to examine the function of miR-92a in HepG2 and ...

Background: Besides their mutagenic, carcinogenic, and teratogenic effects, Aflatoxins (AFs) also act as the main contributor to hepatocellular carcinoma (HCC) which is known as the most common primary liver cancer worldwide. The main aim of this study was risk estimation of HCC due to exposure to aflatoxins in maize from Yogyakarta, Indonesia. Methods: As a model, maize samples were taken fro...