BACKGROUND AND OBJECTIVES The antidepressant amitriptyline is used as an adjuvant in the treatment of a variety of chronic pain conditions. This drug interacts with many receptors and ion channels, such as Na+ channels. In a randomized, double-blinded, and placebo-controlled trial, we investigated whether amitriptyline also is capable of providing cutaneous analgesia when applied topically in 1...

We have read with great enthusiasm the recently published article by Marcel Tschopp and Walter H. Reinhart entitled “Platelet aggregation under high shear conditions during and after a 28-day administration of 100 mg acetylsalicylic acid in healthy volunteers” [1]. They concluded that platelet function as measured by the PFA-100 is not inhibited significantly after a single dose of 100 mg aspir...

Substances existed in tobacco smoke including carcinogens, alkaloids (mainly nicotine), irritants of the respiratory tract and carbon monoxide are known responsible for a wide range of diseases and disorders. The current study was designed to investigate the hematologic effects of smoking. This study is an observational, cross-sectional investigation in which the peripheral blood erythrocytic a...