The ventricular conduction system represents the electrical wiring responsible for the co-ordination of cardiac contraction. Defects in the circuit produce a delay or conduction block and induce cardiac arrhythmias. Understanding how this circuit forms and identification of the factors important for its development thus provide insights into the origin of cardiac arrhythmias. Recent advances, u...

acute yew (taxus baccata) intoxication was induced in 7 adult sheep by oral administration of the plant materials at the dose of 2.5g/kg body weight. blood samples for hematology and serum biochemistry were collected before and after the induced intoxication.electrocardiography was performed using a base-apex lead. intoxicated animals displayed lethargy, depression, bradycardia and varying inte...

myocardial infarction and tobacco smoking: risk of heart rhythm and conduction disorders e imani , msc n hajizadeh , bs z khademy , msc f naghizadeh , bsc received: 6 aug, 2009 accepted: 17 oct, 2009 abstract background & aims: smoking increases risk of myocardial infarction and its complications. in addition, it increases blood pressure, heart rate and vasoconstriction. the purpose of this res...

Arrhythmias figure prominently among the complications encountered in the varied and diverse population of patients with congenital heart disease, and are the leading cause of morbidity and mortality. The incidence generally increases as the patient ages, with multifactorial predisposing features that may include congenitally malformed or displaced conduction systems, altered hemodynamics, mech...

this report describes a 55-year-old woman in whom yellow scorpion sting resulted in the development of mobitz type 1 and transient complete heart blocks unresponsive to atropine administration.  it might be concluded that although autonomic involvement including parasympathetic overactivity is present in such cases, other factors such as toxic damage to the cardiac conduction system may play a ...

This report describes a 55-year-old woman in whom yellow scorpion sting resulted in the development of Mobitz type 1 and transient complete heart blocks unresponsive to atropine administration.  It might be concluded that although autonomic involvement including parasympathetic overactivity is present in such cases, other factors such as toxic damage to the cardiac conduction system may play a ...

DURING the past decade there has been a renewed interest in the distribution of the conduction system of the heart. Although the presence of such a system was questioned in the past,' the excellent studies of several investigators2-4 during recent years have reaffirmed its presence with descriptions of the histologic nature5 and anatomic course of the conduction system for human and animal hear...

Normal heart function is critically dependent on the timing and coordination provided by a complex network of specialized cells: the cardiac conduction system. We have employed functional assays in zebrafish to explore early steps in the patterning of the conduction system that previously have been inaccessible. We demonstrate that a ring of atrioventricular conduction tissue develops at 40 hou...

BACKGROUND Recent studies in experimental animals have revealed some molecular mechanisms underlying the differentiation of the myocardium making up the conduction system. To date, lack of gene expression data for the developing human conduction system has precluded valid extrapolations from experimental studies to the human situation. METHODS AND RESULTS We performed immunohistochemical anal...

Optical mapping (OM) of cardiac electrical activity conventionally collects information from a three-dimensional (3-D) surface as a two-dimensional (2-D) projection map. When applied to measurements of the embryonic heart, this method ignores the substantial and complex curvature of the heart surface, resulting in significant errors when calculating conduction velocity, an important electrophys...