BACKGROUND & OBJECTIVES The multiple drug resistance (MDR) is a serious health problem and major challenge to the global drug discovery programmes. Most of the genetic determinants that confer resistance to antibiotics are located on R-plasmids in bacteria. The present investigation was undertaken to investigate the ability of organic extract of the fruits of Helicteres isora to cure R-plasmids...

The current study investigated the effect of the aqueous extract of Helicteres isora L (Sterculiaceae) bark on oxidative stress in the brains of rats during diabetes. The aqueous extract of H. isora bark was administered orally (100, 200mg=kg b.w.) and the effect of the extract on blood glucose, plasma insulin, and the levels of thiobarbituric acid reactive substances (TBARS), hydroperoxides, s...

The antioxidant activity of the aqueous (hot) extract of Helicteres isora Linn. (AEHI) (Family—Sterculiaceae) fruits was investigated in various in vitro models. The total polyphenolic content of the extract was found 7.04% of AEHI, when compared to gallic acid and total flavonoids content was 2.4 mg/g of AEHI, when compared to rutin. Hydrogen peroxide radicals were inhibited at IC 50 =165 μg/m...

The present study investigated the possible protective effect of Helicteres isora (Sterculiaceae) bark extracts on certain biochemical markers in streptozotocin (STZ)-induced diabetes in rats. STZ treatment (60 mg/kg/i.p) caused a hyperglycemic state that led to various physiological and biochemical alterations. Blood levels of glucose, urea, uric acid and creatinine, plasma levels of albumin a...

The present study investigated the possible protective effect of Helicteres isora (Sterculiaceae) bark extracts on certain biochemical markers in streptozotocin (STZ)-induced diabetes in rats. STZ treatment (60 mg/kg/i.p) caused a hyperglycemic state that led to various physiological and biochemical alterations. Blood levels of glucose, urea, uric acid and creatinine, plasma levels of albumin a...

the present study investigated the possible protective effect of helicteres isora (sterculiaceae) bark extracts on certain biochemical markers in streptozotocin (stz)-induced diabetes in rats. stz treatment (60 mg/kg/i.p) caused a hyperglycemic state that led to various physiological and biochemical alterations. blood levels of glucose, urea, uric acid and creatinine, plasma levels of albumin a...