islands in the extraembryonic yolk sac. This observation has led to the hypothesis that both cell types originate from a common precursor known as the hemangioblast. This hypothesis has been supported mainly by the co-expression of several genes in both cell types and by in vitro differentiation studies. However, recent studies indicate that primitive blood cells originate from an intermediate ...

Blood and endothelium arise in close association during development, possibly from a common precursor, the hemangioblast [1-4]. Genes essential for blood and endothelial development contain functional ETS binding sites, and binding and expression data implicate the transcription factor, friend leukaemia integration 1 (Fli1) [5-10]. However, loss-of-function phenotypes in mice, although sufferin...

islands in the extraembryonic yolk sac. This observation has led to the hypothesis that both cell types originate from a common precursor known as the hemangioblast. This hypothesis has been supported mainly by the co-expression of several genes in both cell types and by in vitro differentiation studies. However, recent studies indicate that primitive blood cells originate from an intermediate ...

During early vertebrate embryogenesis, both hematopoietic and endothelial lineages derive from a common progenitor known as the hemangioblast. Hemangioblasts derive from mesodermal cells that migrate from the posterior primitive streak into the extraembryonic yolk sac. In addition to primitive hematopoietic cells, recent evidence revealed that yolk sac hemangioblasts also give rise to tissue-re...

The differentiation of embryonic stem (ES) cells offers a powerful approach to study mechanisms implicated in cell fate decision. A major hurdle, however, is to promote the directed and efficient differentiation of ES cells toward a specific lineage. Here, we define in serum-free media the minimal factor requirement controlling each step of the differentiation process, resulting in the producti...

The murine adult hematopoietic stem cell is able to function as a hemangioblast, contributing both to blood reconstitution and to blood vessel repair in response to ischemic injury. We developed a novel mouse xenotransplantation model of retinal neovascularization to test human hematopoietic cell plasticity. Immunocompromised nonobese diabetic (NOD)/scid mice underwent myeloablative conditionin...