hematopoietic stem cell transplantation (hsct) has been practiced for more than 30 years. hematological malignanciesare the main indications for this treatment. however, its indications in adults are different from children.advances in chemotherapy and target therapy have improved treatment outcome of some of the very high riskcancers, and changed indications of hsct in children. multi-center c...

Background: The B-cell defect in X-linked agammaglobulinemia (XLA) is caused by mutations in the gene for Bruton's tyrosine kinase (BTK). BTK mutations result in deficient expression of BTK protein in peripheral blood monocytes. Methods: Using the anti-BTK monoclonal antibody (48-2H), a flow cytometric analysis of intra cytoplasmic BTK protein expression in monocytes was performed to identify I...

background: the b-cell defect in x-linked agammaglobulinemia (xla) is caused by mutations in the gene for bruton's tyrosine kinase (btk). btk mutations result in deficient expression of btk protein in peripheral blood monocytes. methods: using the anti-btk monoclonal antibody (48-2h), a flow cytometric analysis of intra cytoplasmic btk protein expression in monocytes was performed to ident...

Immunophenotyping of leukemias and other hematological neoplasms has become one the most relevant clinical applications flow cytometry which remains an indispensable tool for diagnosis, classification, staging as well hematologic malignancies monitoring. It can provide quantitative data on a number cell parameters large cells in region thousands per second making it powerful diagnostic tool. If...

The WHO classification of tumors of hematopoietic and lymphoid tissues is widely used as a standard for the diagnosis of hematological diseases. However, complicated algorithms developed through the integration of a large amount of laboratory information together with clinical characteristics are employed in most of the diagnostic criteria. Physicians usually have only a limited time to interpr...

purpose: to determine any possible correlation between delayed ocular complications with late-onset complications of mustard gas poisoning in other systems including skin, respiratory tract, and immunohematologic system. methods: the study was conducted on 40 chemical war victims in khorasan province, iran. ophthalmologic and dermatologic examinations and spirometry were performed for all patie...

Multidrug resistance (MDR) is an unwanted phenomenon, that may cause therapy failure in several neoplasms including hematological malignancies. The purpose of any type of laboratory MDR assay is to reliably identify such patients and to provide useful data to clinicians with a relatively short turnaround time. MDR can be multicausal and several previous data identified a group of transmembrane ...

background: cd19 is a pan b cell marker that is recognized as an attractive target for antibody-based therapy of b-cell disorders including autoimmune disease and hematological malignancies. the object of this study was to stably express the human cd19 antigen in the murine nih-3t3 cell line aimed to be used as an immunogen in our future study. methods: total rna was extracted from raji cells i...