OBJECTIVE Copper deficiency has been reported to cause hematological disorders. However, its clinical and hematological characteristics are not fully understood. Therefore, we investigated bedridden patients suffering from copper deficiency and tried to clarify the clinical features of hematological disorders caused by this condition. PATIENTS AND METHODS Five patients with typical copper def...

Liver involvement is often observed in several hematological disorders, resulting in abnormal liver function tests, abnormalities in liver imaging studies, or clinical symptoms presenting with hepatic manifestations. In hemolytic anemia, jaundice and hepatosplenomegaly are often seen mimicking liver diseases. In hematologic malignancies, malignant cells often infiltrate the liver and may demons...

Haematological diseases encompass a wide spectrum of disorders that can present with ocular manifestations. Indeed, ocular manifestations may be the initial indication of an underlying haematological disorder. Blood disorders are one of the major health problems presenting with variable clinical manifestations. Nutritional anemia remains the common haematological abnormality especially in third...

OBJECTIVES The aim of this prospective study was to evaluate the safety and feasibility of laparoscopic splenectomy (LS) in patients with hematological disorders of the spleen. SUBJECTS AND METHODS Between 1999 and 2001, 15 patients (11 female and 4 male), with a mean age of 30 years, underwent LS after preoperative evaluation. If difficulties were encountered in LS, one trocar site incision ...

The aim of the study. Retrospective analysis of indications for splenectomy in hematological diseases, positive effect of this operation and correlations between objective prognostic factors and good response to splenectomy in patients with different hematological indications for splenectomy. Material and methods. 98 adult patients with hematological disorders, who were splenectomised in the ye...

background human t-cell lymphotropic virus types ι and ιι (htlv-ι and htlv-ii) are deltaretroviruses which may cause leukemia, lymphoma and htlv-associated myelopathy/tropical spastic paraparesis (ham/tsp). in addition, htlv-1 may be related to thalassemia and hemophilia cases after blood transfusion. objectives the aim of this study was evaluation of the prevalence of htlvs in patients with he...

Aim: To determine the frequency of non malignant hematological causes of pancytopenia. Bone marrow examination of 148 cases of suspected hematological disorders was carried out in a DHQ KDA Hospital, Kohat from Jan. 2011to Dec. 2013. Results: Among the non malignant hematological disorders, megaloblastic anemia was the most common disorder i.e., (18.2%) followed by aplastic anemia (8.8%), ITP (...

Pulmonary hypertension (PH), a serious disorder with a high morbidity and mortality rate, is known to occur in a number of unrelated systemic diseases. Several hematological disorders such as sickle cell disease, thalassemia and myeloproliferative diseases develop PH which worsens the prognosis. Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction. Pulmon...

Extracellular vesicles (EVs), comprised of exosomes, microparticles, apoptotic bodies, and other microvesicles, are shed from a variety of cells upon cell activation or apoptosis. EVs promote clot formation, mediate pro-inflammatory processes, transfer proteins and miRNA to cells, and induce cell signaling that regulates cell differentiation, proliferation, migration, invasion, and apoptosis. T...