s: Carbamazepine (CBZ) intoxication can be associated with severe toxicity. Highly protein-bounded, CBZ is not removed efficiently through conventional hemodialysis. we observed that serum CBZ level was decreased minimally by albumin-enhanced CVVHDF with low dialysate flow. Therefore, albumin-enhanced CVVHDF with high dialysate flow should be considered in severe CBZ intoxication, if hemoperfus...

Abstract Background and Aims Cytokine storm in COVID-19 is an excessive immune response through the overproduction of inflammatory cytokines which significantly increases mortality. Hemoperfusion has been granted Emergency Use Authorization (EUA) by Food Drug Administration (FDA) effort to eliminate circulating mediators among critical patients improve clinical outcomes survival. This study aim...

a carbamazepine intoxication with attempt is a relatively common clinical problem that presenting with coma, respiratory depression, arrhythmia, hemodynamic instability and even death. we report a case of severe carbamazepine poisoning that was successfully treated with one session charcoal hemoperfusion. on admission, the patient was comatose and required ventilator support. hemoperfusion with...

A carbamazepine intoxication with suicide attempt is a relatively common clinical problem that presenting with coma, respiratory depression, arrhythmia, hemodynamic instability and even death. We report a case of severe carbamazepine poisoning that was successfully treated with one session charcoal hemoperfusion. On admission, the patient was comatose and required ventilator support. Hemoperfus...

Objective: This study aimed to determine the dialyzability of common pesticide surfactants. Methods: Hemodialysis and hemoperfusion were performed for three surfactants-sodium dodecylbenzenesulfonate, lignosulfonic acid sodium, and naphthalenesulfonic acid polymer with formaldehyde-with buffer solutions (2 L) containing 0.2% surfactant with or without bovine serum albumin (3.0 g/dL). Results: T...

Methods This ancillary study of the ABDOMIX study investigated the impact of two PMX-HP sessions on day 28 mortality in peritonitis-induced septic shock, blood samples were performed within 10 hours post-surgery (P1), at the end of the first hemoperfusion session in the experimental group or 2 hours after P1 in the control group (P2), 24 hours after P1 (P3), and at the end of the second hemoper...

BACKGROUND Septic shock is common and has unacceptably high morbidity, mortality, and associated cost with numerous failed attempts at developing effective therapies. Endotoxin, one of the most potent mediators of sepsis, is found in high levels in approximately 50% of patients with septic shock. Polymyxin B (PMX) hemoperfusion has been shown in numerous studies to successfully remove endotoxin...

BACKGROUND/AIMS Substances in the middle molecular weight range have been shown to play a significant pathogenetic role in as diverse disorders as end-stage renal disease and multiple organ failure. To overcome the limitations in the amount removed by hemofilters, new sorbents with a high biocompatibility are actively being developed. Furthermore, biocompatible sorbents by their nonspecific ads...

Background: The differences of Hemodialysis and Hemoperfusion’s combination can increase Uremic Toxin clearance, average creatinine Angiotensin elimination optimally. hemodialysis hemoperfusion’s also decrease blood pressure reduce the use Anti Hypertension drugs so that number cardiac events in CKD patients may decrease. ABPM is chosen because this best method automatic which has most ac...

A modified filmadsorber is presented, intended to be used for selective and specific hemoperfusion. It consists of a spirally wound cellulose nitrate film, onto which--after chemical activation with sodium periodate--albumin is bound, stabilized, sterilized and activated with glutaraldehyde. Various bioactive ligands containing amino groups can be coupled to this support. A subsequent treatment...