We attempted to clarify the storage iron metabolism from the change in the serum ferritin level. We assumed that the nonlinear decrease in serum ferritin was caused by serum ferritin increase in iron mobilization. Under this assumption, we determined both ferritin and hemosiderin iron levels by computer-assisted simulation of the row of decreasing assay-dots of serum ferritin in 11 patients wit...

word count: 200) Quantification of hemosiderin-laden macrophages in the bronchoalveolar lavage fluid (BALF) has been used to diagnose diffuse alveolar hemorrhage (DAH) but has not been assessed in patients with diffuse alveolar damage (DAD). The current study analyzed BALF obtained in 21 patients with DAD diagnosed by surgical lung biopsy. The median age of 21 patients with DAD was 68 years (ra...

Endogenous tissue iron, other than that in blood, occurs primarily in two MRI detectable forms: ferritin iron and hemosiderin iron [1]. Ferritin is a water soluble protein with an iron core and is the body’s main iron storage protein. Hemosiderin iron is water insoluble and consists largely of ferrihydrite. Ferritin may either be diffusely dispersed or localized in specific cells, depending on ...

Ferritin iron, hemosiderin iron, total iron stores and transformation rate were determined by serum ferritin kinetics. The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them. The transformer determines transformation rate according to the potential difference in iron mobilization and deposition. The correlations between transformation rate...

In the coutrse of a prospective, controlled evaluation of the effect of portacaval anastomosis on hepatic lhemosidlerin deposition(l), a large number of iron-stained slicles were evaltuated blindly, semniquantitatively and serially. Those slides in wlhichi excessive deposition of hemosiderin was present microscopically appeared blue in color to gross inspection while those in whiom little or no...

By G. W. RIciiTER AND M. C. BEssIs T HE TERM HEMOSIDERIN (“H#{228}mosiderin”) was proposed by Neumann1 though others had earlier recognized the material to which the word refers, notably Perls.2 Neumann’s definition was clearly based on histologic and histochemical criteria : brown granules giving certain reactions for iron, particularly the Prussian ( Berlin ) blue test, as seen in situ in cel...

In the spleen, liver, and kidneys of most mammals may be found varying quantities of yellow-brown granules and to these granules has been given the general name hemosiderin. Since the formation and location of hemosiderin coincides in time and place with the destruction of blood, the idea has become firmly established that hemosiderin represents some step in the disintegration of hemoglobin and...

Hemosiderinuria caused by intravascular hemolysis is a characteristic clinical feature of an acquired hemolytic disorder, paroxysmal nocturnal hemoglobinuria (PNH). We examined the deposition of hemosiderin (iron) in the kidneys of 6 patients with PNH using magnetic resonance imaging (MRI). Three patients with autoimmune hemolytic anemia (AIHA), a hemolytic disorder showing extravascular hemoly...