نتایج جستجو برای: hepatic stellate cell
تعداد نتایج: 1763684 فیلتر نتایج به سال:
The liver parenchyma is populated by hepatocytes and several nonparenchymal cell types, including Kupffer cells and hepatic stellate cells. Both Kupffer cells and hepatic stellate cells are responsive to the chemokine CCL2, but the precise roles of CCL2 and these cells in liver tumor formation remain undefined. Hence, we investigated the effects of the lack of the major CCL2 receptor, CCR2, on ...
In article number 2007425, Junmin Lee, Ali Khademhosseini, and co-workers present a breakthrough for modeling of non-alcoholic fatty liver disease (NAFLD) based on bioengineered multicellular microtissues liver-on-a-chip system. The consisting four major cell types (primary human hepatocytes, stellate cells, Kupffer endothelial cells) recapitulate the pathogenesis hepatic fibrosis driven by NAF...
HCC is marked by genetic heterogeneity and activated hepatic stellate cells (HSC) are considered key players during development. The paracrine effect of different cell lines on the activation primary hHSC was accompanied differential AMPK depending line used. Pharmacological treatment inhibited HCC-induced through AMPK-dependent AMPK-independent mechanisms. This heterogenic confirmed data minin...
Liver fibrosis occurs as a wound-healing scar response following acute and chronic liver inflammation including alcoholic liver disease, non-alcoholic steatohepatitis, hepatitis B and C, and autoimmune hepatitis. Myofibroblasts, mainly transdifferentiated from hepatic stellate cells, are pivotal cell types that produce fibrillar collagen. The activation of inflammatory cells, including Kupffer ...
Hepatic stellate cells are believed to play a key role in the development of liver fibrosis. Several studies have reported that bone marrow cells can give rise to hepatic stellate cells. We hypothesized that hepatic stellate cells are derived from hematopoietic stem cells. To test this hypothesis, we generated chimeric mice by transplantation of clonal populations of cells derived from single e...
Hepatocellular carcinoma is a common cancer in Asia with a poor prognosis. Tumour encapsulation has been shown to be a good, independent prognostic factor. The main cell in the liver responsible for extracellular matrix formation is the hepatic stellate cell, and this was investigated as the cell type responsible for encapsulation. This lecture discusses the role of hepatic stellate cells in he...
Hepatic stellate cells are believed to play a key role in the development of liver fibrosis. Several studies have reported that bone marrow cells can give rise to hepatic stellate cells. We hypothesized that hepatic stellate cells are derived from hematopoietic stem cells. To test this hypothesis, we generated chimeric mice by transplantation of clonal populations of cells derived from single e...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید