Blood platelets have essential roles in hemostasis and thrombosis, inflammation, host defense, and wound healing. Emerging evidence from recent in vitro and in vivo studies suggests that platelets have a pivotal role in liver regeneration. In experimental animal models in which platelets were depleted or functionally impaired, liver regeneration after a partial liver resection was substantially...

severe hepatic failure accounts for many deaths and raises medical costs each year worldwide. currently, liver transplantation is the most common therapeutic option for patients with end-stage chronic liver disease. due to decrease in the number of organ donors, many in need of transplantation continue to remain on the waiting list. hepatic tissue engineering is a step toward alleviating the ne...

introduction: intracellular ph (phi) regulates essentially all aspects of cellular activities. however, it is unknown how endoplasmic reticulum (er) potassium channels sense phi. in this study, we investigate the direct effects of phi on er potassium channels. methods: we used channel incorporation into the bilayer lipid membrane method. l-α-phosphatidylcholine, a membrane lipid, was extracted ...

the mediterranean flour moth, ephestia kuehniella zeller, is one of the major pests in stored products worldwide. several problems assossiated with the use of conventional insecticides have strongly demonstrated the need for applying alternative safe compounds such as insect growth regulators (igrs). in the present study, growth regulating activity and hematological effects of pyriproxifen and ...

GENERAL ASPECTS OF HEPATOCYTE GROWTH FACTOR STRUCTURE AND FUNCTION 612 Biochemical and Structural Properties of Hepatocyte Growth Factor Protein 612 Pathways of Activation of Hepatocyte Growth Factor 612 Structure–Function Analysis of the Hepatocyte Growth Factor Molecule 613 Hepatocyte Growth Factor Gene Organization 613 Hepatocyte Growth Factor Gene and Its Transcriptional Control 614 Hepatoc...

background because of varying reports, there is still need to investigate the impact of wrestling on hematological indices. objectives we investigated differences in the basic hematological indices in wrestlers compared to sedentary controls. patients and methods the blood samples containing anticoagulant were collected from 12 male elite wrestlers (age = 24 ± 1.2 years, weight = 76 ± 5 kg) wit...

Background: Wharton’s jelly is an unlimited source of stem cells that can be used in cell therapy and tissue engineering without any ethical concern. It has been revealed the cell-free extract could be effective to induce cell differentiation. The objective of this study was to induce Wharton’s jelly-derived mesenchymal stem cells (MSCs) into hepatocyte-like cells by premeabilization of the cel...

background: in recent years we have successfully adopted an in vitro hepatogenic differentiation of mesenchymal stem cells (mscs). in this protocol the biologically active hepatocyte-like cells were differentiated from the stem cells isolated from either bone marrow or umbilical cord blood (ucb) samples. the aim of the present study was to compare the efficiency of the hepatogenic differentiati...

background: wharton’s jelly is an unlimited source of stem cells that can be used in cell therapy and tissue engineering without any ethical concern. it has been revealed the cell-free extract could be effective to induce cell differentiation. the objective of this study was to induce wharton’s jelly-derived mesenchymal stem cells (mscs) into hepatocyte-like cells by premeabilization of the cel...

Celiac disease can present with extraintestinal manifestations, including liver disease, a spectrum ranging from elevated biochemistries to advanced cirrhosis. Liver biopsy findings may include variable degrees of steatosis, inflammation, and fibrosis. In one case, we have seen the patient presented unexplained ascites features suggestive Budd-Chiari syndrome. The serum-ascites albumin gradient...