Hepatosteatosis is characterized by an aberrant accumulation of triglycerides in the liver; however, the factors that drive obesity-induced fatty liver remain largely unknown. Here, we demonstrated that the secreted cell adhesion protein periostin is markedly upregulated in livers of obese rodents and humans. Notably, overexpression of periostin in the livers of WT mice promoted hepatic steatos...

OBJECTIVE Childhood-onset obesity is associated with increased mortality and morbidity related to cardiovascular diseases (CVD) during adulthood. Dyslipidemia has a fundamental role in the pathogenesis of CVD. This study aimed to evaluate the prevalence of dyslipidemia and related factors among obese children and adolescents. METHODS Obese patients aged between 2 and 18 years were included in...

OBJECTIVE Childhood obesity is related to subclinical atherosclerosis. Carotid intima-media thickness (CIMT) and hepatosteatosis are parameters that reflect subclinical atherosclerosis and are shown to be associated with obesity. However, their relation with the corrected QT interval (QTc) has not been thoroughly studied in children. Here, we aimed to research the relation between QTc, hepatic ...

Hepatosteatosis is associated with the development of both hepatic insulin resistance and Type 2 diabetes. Hepatic expression of Cd36, a fatty acid transporter, is enhanced in obese and diabetic murine models and human nonalcoholic fatty liver disease, and thus it correlates with hyperinsulinemia, steatosis, and insulin resistance. Here, we have explored the effect of hyperinsulinemia on hepati...

background: hepatic steatosis due to estrogen therapyincreases the activity of inflammatory markers, particularly theactivity of tnfα which in turn induces more lipogenesis.omega-3 fatty acids are among the negative regulators of hepaticlipogenesis. objectives: in this research, the preventive effectof omega-3 fatty acids on estrogen-induced steatosis in rats wasevaluated. methods:2 mg/kg. bw/s...

BACKGROUND/AIMS Non-alcoholic fatty liver disease is associated with insulin resistance. Compound K (CK) is the final metabolite of panaxadiol ginsenosides that have been shown to exert antidiabetic effects. However, the molecular mechanism of the antidiabetic effects in the liver have not been elucidated; further, whether CK has beneficial effects in hepatosteatosis remains unclear. Therefore,...

Purpose: The aim of study was to determine the relation vitamin D receptor gene (VDR) polymorphisms TaqI (rs731236), ApaI (rs7975232), BsmI (rs1544410), FokI (rs10735810) with risk obesity, metabolic syndrome and hepatosteatosis in children.Materials methods: 130 obese healthy children age range between 10-16 years included this study. Anthropometric measurements, biochemical evaluations abdomi...

Objectives: The aim of the study was to investigate relationship between body mass index and ultrasound-measured subcutaneous adipose tissue (SCAT) thickness, in order propose an alternative non-invasive inexpensive method measure fat. We also evaluated liver size existence hepatosteatosis, investigated whether there a measurements (BMI), SCAT measurements. Methods: Height, weight, arm SCAT, um...

BACKGROUND Insulin signaling comprises 2 major cascades: the insulin receptor substrate/phosphatidylinositol 3'-kinase/protein kinase B and Ras/Raf/mitogen-activated protein kinase/kinase/ERK pathways. While many studies on the tissue-specific effects of the insulin receptor substrate/phosphatidylinositol 3' -kinase/protein kinase B pathway have been conducted, the role of the other cascade in ...

OBJECTIVE(S) Non-alcoholic steatohepatitis (NASH) is a chronic liver disease with unknown etiology. The insulin resistance, immune mechanisms and oxidative stress are the main factors in its pathogenesis. Dipeptidyl peptidase IV (DPPIV) or CD26 is a protein with endocrine and immune functions. This study aimed to elicudate the changes related to DPPIV in NASH patients. METHODS Serum and urina...