Neuropathic pain develops from a lesion or disease affecting the somatosensory system. Translational investigations of neuropathic pain by using different animal models reveal that peripheral sensitization, spinal and cortical plasticity may play critical roles in neuropathic pain. Furthermore, descending facilitatory or excitatory modulation may also act to enhance chronic pain. Current clinic...

Astragali Radix, the root of Astragalus membranaceus Bunge, is a crude drug used widely in Oriental medicines. It is a major component of Ougi-Keishi-gomotsu-to, a traditional herbal medicine, used for neurop patients with abnormal sensations and neuropathic pain of the legs. It was shown to have inhibitory effects on lipid peroxidation and protein oxidative modification by copper. The effects ...

The aim of our study was to determine the levels of information and awareness of the nurses who work on neuropathic pain in the departments of physical medicine and rehabilitation, neurology and neurosurgery. A total of 60 nurses (20 per each department) who work in the physical medicine and rehabilitation, neurology and neurosurgery departments of Beyhekim State Hospital of Konya in Turkey too...

BACKGROUND Neuropathic pain is generally defined as a chronic pain state resulting from peripheral and/or central nerve injury. There is a lack of effective treatment for neuropathic pain, which may possibly be related to poor understanding of pathological mechanisms at the molecular level. Curcumin, a therapeutic herbal extract, has shown to be effectively capable of reducing chronic pain indu...

BACKGROUND Alternative medicine is noted for its clinical effect and minimal invasiveness in the treatment of neuropathic pain. Go-sha-jinki-Gan, a traditional Japanese herbal medicine, has been used for meralgia and numbness in elderly patients. However, the exact mechanism of GJG is unclear. This study aimed to investigate the molecular mechanism of the analgesic effect of GJG in a chronic co...

There has been increasing interest in exploring the potential therapeutic benefit of the botulinum toxins in the management of neuropathic pain. Examples of neuropathic pain include painful diabetic polyneuropathy, postherpetic neuralgia (PHN), complex regional pain syndrome, trigeminal neuralgia and neuropathic low back pain. Other chronic pain syndromes may exhibit neuropathic features includ...

Neuropathic pain originates from a lesion within the central or peripheral nervous system. The signs of neuropathic pain include heat hyperalgesia, mechanohyperalgesia, and mechanoand cold allodynia. Traditionally, neuropathic pain responds poorly to conventional analgesics. This chapter will provide recommendations for medical and interventional management of neuropathic pain conditions based ...

OBJECTIVE To examine the profile and treatment pattern of patients with neuropathic pain attending Siriraj Pain Clinic. MATERIAL AND METHOD A 2-year retrospective study of the prevalence of neuropathic pain, characteristics of the patients and the use of medical treatment. Records of all the patients that attended Siriraj Pain Clinic from September 1, 2002 until September 30, 2004 were review...