objective(s) herpes simplex viruses (hsvs) have widespread and ubiquitous prevalence in the human population and they have received a great deal of attention due to the range of diseases, they caused as a result of an infection. it seems that the fast and reliable diagnostic methods are needed for detecting the herpes simplex virus type 1 (hsv1) antibodies especially in patients with hsv enceph...

background: human pathogens that can cause infertility may also affect sperm count and quality. viral infections can be considered as direct and/or indirect cause of male factor infertility. objective: our goal was to investigate the prevalence of herpes simplex virus in the semen of infertile men attending the avicenna infertility clinic, and to compare it with the herpes virus serology result...

background and aims: the latency-associated transcript (lat) transcribed by latent herpes simplex virus type-1 in neuron cells are able to influence their host cell pathways. while the most of previous studies were focused on anti-apoptotic effects of lat, our investigation is making an effort to explore lat potency on cell cycle pathway in neuroblastoma cell lines. methods: the evaluation of l...

a complication in the analysis of the role of icp34.5 gene in the herpes simplex virus type-1 (hsv-1) lifecycle is the presence of overlapping antisense gene, open reading frame p (orf p), which is also deleted in hsv-1 icp34.5 negative mutants. a hsv-1 wild type strain (17+) icp34.5/orf p deletion mutant (1716) is totally avirulent in animal models and impaired in a number of in vitro function...

background and aims: several drugs are being used in treatment of hsv infection in human but still introducing an effective safe drug is desirable. methods: we investigated the inhibitory effect of morphine on replication of hsv in vitro. results: the results indicated that a concentration of up to 200 ug/ml morphine had a limited effect on vero cell viability. at this concentration the growth ...

Herpes simplex virus type 1 is an important epithelial pathogen and has the potential for significant morbidity in humans. Here we demonstrate that a cell surface scavenger receptor, macrophage receptor with collagenous structure (MARCO), previously thought to enhance antiviral defense by enabling nucleic acid recognition, is usurped by herpes simplex virus type 1 and functions together with he...

We prepared mouse hybrid cell lines which produced antibodies against herpes simplex virus type 1 and 2 nucleocapsids. Cell lines 1D4 and 3E1, respectively, secreted immunoglobulin G1 herpes simplex virus type 1 and immunoglobulin G1 herpes simplex virus type 2 antibodies which immunoprecipitated proteins designated p40 and p45 from homologous nucleocapsid preparations but precipitated no prote...

herpes simplex esophagitis (hse) has rarely been reported in immunocom­petent individuals. in a search of medline until october 2012, we found only one case of hse in a pregnant female. we present the first case of hse in a healthy 36-year-old female at 27 weeks gestation who recovered without an­tiviral therapy. normal 0 false false false en-us x-none fa

Background: The diagnosis of herpes simplex virus may requirevirological confirmation. Tzanck smear is an old, rapid, costeffective but nonspecific method that has been recently re-evaluatedas a method for the diagnosis of herpes virus infection. This studywas conducted to compare Tzanck smear and viral culture in thediagnosis of herpes simplex virus infection in patients clinicallysuspected to...

herpes simplex virus (hsv) causes a wide range of pathologies in the human central nervous system (cns) such as stroke. it was proposed that there is an association between hsv infection and stroke with different results reported by the researchers using different methods. this study aimed to investigate the frequency of hsv among stroke patient and control groups. we detected hsv in 28 stroke ...