herpes simplex virus (hsv) causes a wide range of pathologies in the human central nervous system (cns) such as stroke. it was proposed that there is an association between hsv infection and stroke with different results reported by the researchers using different methods. this study aimed to investigate the frequency of hsv among stroke patient and control groups. we detected hsv in 28 stroke ...

conclusions: prevalence of hsv1/2 in mucocutaneous biopsies from pemphigus patients is 2.5% and possibly hsv1/2 has no role in the pathogenesis of pemphigus lesions. but resistant cases to treatment might be suspected to hsv. results: ten patients (25%) had a history of orolabial herpes infection. the results of all samples were negative for hsv1 except one sample which showed the positive resu...

herpes simplex virus type 1 (hsv-1) with a worldwide distribution has been reported in all human populations, resulting in a clinical spectrum of infections. although hsv type 2 (hsv-2) is known as the most common cause of genital herpes, an increasing number of cases with genital herpes are caused by hsv-1. the present study aimed to discuss the changes in the epidemiology of hsv-1 infection i...

conclusions herpes simplex virus was present in more patients with ms than healthy cases. hsv may be directly or indirectly associated with ms development. further comprehensive molecular studies are needed to confirm the etiopathologic association between hsv and ms disease. results totally, 63 (76.8%) patients with ms showed a history of hsv exposure by anti-hsv testing compared to 70 (78.7%)...

background :wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. we investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (hsv-1) in cell culture.   methods : in-vitro c...

Brown alga, Turbinaria conoides was successively extracted with n-hexane, cyclohexane, methanol and ethanol:water (1:1). The extracts were evaluated for antibacterial and antifungal activities by disc diffusion method. Minimal inhibitory concentration was determined for active extracts by broth dilution method. The antiviral activity and cytotoxicity of the extracts were tested in human embryon...

objective: herpes simplex virus (hsvs) is a widespread human infectious agent, responsible for persistent and latent infections. herpes simplex virus infections are usually continually recurrent in the normal population and represent a significant cause of complications in immunocompromised patients. materials and methods: in this study hsvs were propagated in bk cells and more than 502 sample...

    Acyclovir (9-[2-hydroxyethoxymethyl] guanine) is an acyclic nucleoside analogue of guanosine which is a potent and selective antiviral agent. Acycloviris converted to the monophosphate by thymidine kinase the virus-specific form of this enzyme and is subsequently converted to the triphosphate by the host cell kinase. Acyclovir triphosphate inhibits viral DNA-polymerase terminating the chain...