Research on relationships between anxiety and depression has proceeded at a rapid pace since the 1980s. The similarities and differences between these two conditions, as well as many of the important features of the comorbidity of these disorders, are well understood. The genotypic structure of anxiety and depression is also fairly well documented. Generalized anxiety and major depression share...

Heterogeneous multiand many-core systems are increasingly prevalent in the desktop and mobile domains. On these systems it is common for programs to compete with co-running programs for resources. While multi-task scheduling for CPUs is a well-studied area, how to partitioning and map computing tasks onto the hetergeneous system in the presence of GPU contention (i.e. multiple programs compete ...

Extracellular shed vesicles, including exosomes and microvesicles, are disseminated throughout the body and represent an important conduit of cell communication. Cancer-cell-derived microvesicles have potential as a cancer biomarker as they help shape the tumor microenvironment to promote the growth of the primary tumor and prime the metastatic niche. It is likely that, in cancer cell cultures,...

Single cell gene expression studies enable profiling of transcriptional regulation during complex biological processes and within highly hetergeneous cell populations. These studies allow discovery of genes that identify certain subtypes of cells, or that mark a particular intermediate states during a biological process. In many single cell studies, individual cells are executing through a gene...

Although the number of transistors per microprocessor core has increased over the last decade, this increase in complexity has caused only a modest increase in application performance. Most performance improvements can be traced to faster clock rates from technology scaling. While complex, wide-issue, superscalar cores provide higher single-thread performance, they are often poorly suited to ap...

GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85. We tested eight GAB2 variants in four North American Caucasian case-control series (2,316 LOAD, 2,538 controls) for association with LOAD. Meta-analyses revealed ORs ranging from (0.61-1.20) with no signi...

ion is a key tool for allowing engineers to think about the system being developed. Keeping the data consistent across abstraction levels can be a challenge. As mentioned earlier, E10A is now updating their system model to use composite classes and ports with the goal of the tool providing significant support for keeping the abstraction levels synchronized. 5. Conclusions and Way Ahead The appl...

Marked discrepancies (values up to four times higher in on assay than in the other) were observed when the plasma concentration of immunoreactive human calcitonin (iCT) was measured by two radioimm8noassays in 18 patients with medullary thyroid carcinoma. The two antisera used had different binding affinities for the NH2- and COOH-terminal regions of synthetic calcitonin monomer (CT-1-32). Exce...

Extended Abstract The development of complex software-intensive systems requires stakeholders from diverse domains to work in a coordinated manner on different aspects of the system. Model-driven engineering (MDE) helps in reducing the gap between heterogeneous domains using principles of separation of concerns, automatic generation and domain-specific languages (DSL). Therefore MDE is a potent...

This paper has two complementary focuses. The first is the system design and algorithmic development for air traffic control (ATC) using an associative SIMD processor (AP). The second is the comparison of this implementation with a multiprocessor implementation and the implications of these comparisons. This paper demonstrates how one application, ATC, can more easily, more simply, and more eff...