A heterocyclic compound is a cyclic compound that has atoms of at least two different elements as members of its ring(s). The counterparts of heterocyclic compounds are homo cyclic compounds although heterocyclic compounds may be inorganic, most contain at least one carbon. Since in organic chemistry non-carbons usually are considered to replace carbon atoms, they are called heteroatoms, meanin...

We report the strategic use of cyclohexyne and the more elusive intermediate, cyclopentyne, as a tool for the synthesis of new heterocyclic compounds. Experimental and computational studies of a 3-substituted cyclohexyne are also described. The observed regioselectivities are explained by the distortion/interaction model.

Pyrrole is a heterocyclic aromatic organic compound, a five-membered ring with the formula C4H4NH. It is a colourless volatile liquid that darkens readily upon exposure to air. Substituted derivatives are also called pyrroles, e.g., N-methylpyrrole, C4H4NCH3. Porphobilinogen, a trisubstituted pyrrole, is the biosynthetic precursor to many natural products such as heme. A heterocyclic compound i...

The validity of calculated NMR shifts to predict the outcome of electrophilic aromatic substitution reactions on different heterocyclic compounds has been examined. Based on an analysis of >130 literature examples, it was found that the lowest predicted (13)C and/or (1)H chemical shift of a heterocycle correlates qualitatively with the regiochemical outcome of halogenation reactions in >80% of ...

Heterocyclic scaffolds represent the key structural subunits of many biologically active compounds. Over the last few years iodine-mediated reactions have been extensively studied due to their low cost and eco-friendliness. This Review covers advances in the field of iodine-mediated synthesis of heterocyclic compounds since 2006, especially with an emphasis on mechanisms of ring formation. In t...

MARIA NEGOIU1, SIMONA PASCULESCU1*, TUDOR ROSU1, RODICA GEORGESCU2, CONSTANTIN DRAGHICI3 1University of Bucharest, Faculty of Chemistry, Inorganic Chemistry Department, 23 Dumbrava Rooie, 020461, Bucharest, Romania 2 Institute of Engineering and Nuclear Physics, 407 Atomistilor Str., PO Box M G 6, Bucharest-Magurele, Romania 3 Romanian Academy, Center for Organic Chemistry “C.D. Nenitescu), 202...