Peptide based self-assembled structures, especially those from smaller peptides, have attracted much research interest due to their potential applications as biomaterials. These structures have been produced using different solvents (one of the methods), including alcohols, except fluorinated alcohols, which are believed to support non-aggregated structures. Herein, we have studied the ability ...

This work reports on the first study of thermal transport capacity in the thickness direction (wmm scale) for spider silk films. Fresh (minimally processed) and hexafluoroisopropanol (HFIP) films of Nephila clavipes and Latrodectus hesperus major ampullate silk are studied. Detailed Raman spectroscopy reveals that the fresh films have more crystalline secondary protein structures such as antipa...

The impact of synthetic amyloid β (1-42) (Aβ(1-42)) oligomers on biophysical properties of voltage-gated potassium channels Kv 1.3 and lipid bilayer membranes (BLMs) was quantified for protocols using hexafluoroisopropanol (HFIP) or sodium hydroxide (NaOH) as solvents prior to initiating the oligomer formation. Regardless of the solvent used Aβ(1-42) samples contained oligomers that reacted wit...

Ionic liquids with the weakly coordinating perfluoroalkoxyaluminate anions, Al(ORF)4-, are obtained by a metathesis reaction of LiAl(ORF)4 and [bmim]Cl or [bmpyr]Cl in high yields. The compounds [bmim][Al(hfip)4] and [bmpyr][Al(hfip)4] have surprisingly low viscosities at elevated temperatures (60 degrees C) and an exceptionally high electrochemical window, which might render them useful for ce...

To understand how the conformational heterogeneity of protofibrils formed by any protein, as well as the mechanisms of their formation, are modulated by a change in aggregation conditions, we studied the formation of amyloid protofibrils by barstar at low pH by multiple structural probes in the presence of hexafluoroisopropanol (HFIP). In the presence of 10% HFIP, aggregation proceeds with the ...

Cold denaturation is a general phenomenon in globular proteins, and the associated cold-denatured states of proteins have important fundamental and practical significance. Here, we have characterized the cold-denatured state of a beta-hairpin forming peptide, MrH3a, in 8% hexafluoro-2-propanol (HFIP) and the dynamics of its refolding following a laser-induced T-jump. Beta-hairpins constitute an...

BackgroundThe volatile anaesthetic sevoflurane protects cardiac tissue from reoxygenation/reperfusion. Mitochondria play an essential role in conditioning. We aimed to investigate how and its primary metabolite hexafluoroisopropanol (HFIP) affect necrosis, apoptosis, reactive oxygen species formation cardiomyocytes upon hypoxia/reoxygenation injury. Moreover, we describe the similarities mode o...

The oxidative dehydrogenation of N-heterocyclic compounds by using H2O2 as oxidant in combination with polar solvents such 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) and H2O is described. Among these two solvents, the best yields for heteroaromatic were generally achieved HFIP. However, it remarkable, that use a non toxic solvent gave good yields. Furthermore, procedure was implemented larger-sca...

Merging the latest advances in field of gold catalysis and efficiency hexafluoro-2-propanol (HFIP), a gold-catalyzed orthogonal tandem reaction has been developed to access carbocyclic ketone on naphthalene substrates. The methodology involved cycloisomerization/nucleophilic addition C→O rearrangement. HFIP solvent most probably acted as Lewis-acid isochromene derivatives, through hydrogen dono...

Electrochemical dehalogenation of polyhalogenated compounds is an inefficient process as the working electrode passivated by deposition short-chain polymers that form during early stages electrolysis. Herein, we report use 1, 3, 3-hexaflouroisopropanol (HFIP) efficient reagent to control C–H formation over radical association. Debromination 1,6-dibromohexane was examined in presence Ni(II) sale...